La recherche fondamentale en biologie au CHU de Poitiers, c’est :<\/p>\n
<\/p>\n
<\/p>\n
Directeur\u00a0 : Pr G\u00e9rard MAUCO<\/strong><\/span><\/p>\n Effectifs (au 1\/01\/2010)<\/span><\/strong><\/p>\n Nom, Pr\u00e9nom<\/p>\n<\/td>\n Grade et fonction<\/p>\n<\/td>\n Organisme de rattachement<\/p>\n<\/td>\n HDR (oui\/non)<\/p>\n<\/td>\n<\/tr>\n EUGENE Michel<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n FAVREAU Fr\u00e9d\u00e9ric<\/p>\n<\/td>\n ma\u00eetre de conf\u00e9rence des universit\u00e9s-ph<\/span><\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n GOUJON Jean-Michel<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n HADJADJ Samy<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n HAUET Thierry<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n LEVILLAIN Pierre<\/p>\n MAIXENT Jean-Michel<\/p>\n<\/td>\n pu-ph<\/p>\n pu<\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n MAUCO G\u00e9rard<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n RICHER Jean-Pierre<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n ROBERT Ren\u00e9<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n SEGUIN Fran\u00e7ois<\/p>\n<\/td>\n pu<\/p>\n<\/td>\n Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n TOUCHARD Guy<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU et Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n BADET Lionel<\/span><\/p>\n<\/td>\n pu-ph<\/span><\/p>\n<\/td>\n Hospices civils de Lyon<\/p>\n<\/td>\n oui<\/p>\n<\/td>\n<\/tr>\n BARROU Beno\u00eet<\/span><\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n AP-HP<\/p>\n<\/td>\n oui<\/p>\n<\/td>\n<\/tr>\n HANNAERT Patrick<\/p>\n<\/td>\n CR1 CNRS<\/span><\/p>\n<\/td>\n CNRS<\/p>\n<\/td>\n Oui<\/p>\n<\/td>\n<\/tr>\n CAU J\u00e9r\u00f4me<\/p>\n<\/td>\n ph<\/p>\n<\/td>\n CHU de Poitiers<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n JAYLE Christophe<\/p>\n<\/td>\n ph<\/p>\n<\/td>\n CHU de Poitiers<\/p>\n<\/td>\n non<\/p>\n<\/td>\n<\/tr>\n CHATAURET Nicolas<\/p>\n<\/td>\n Post-doctorant<\/p>\n<\/td>\n Contractuel ANR<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n GIRAUD S\u00e9bastien<\/p>\n<\/td>\n Ing\u00e9nieur<\/p>\n<\/td>\n CHU de Poitiers<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n THUILLIER Raphael<\/p>\n<\/td>\n Ing\u00e9nieur<\/p>\n<\/td>\n CHU de Poitiers<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n FERNANDEZ B\u00e9atrice<\/p>\n<\/td>\n Ing\u00e9nieur<\/p>\n<\/td>\n CHU de Poitiers<\/p>\n<\/td>\n QUELLARD Nathalie<\/p>\n AMETEAU Virginie<\/p>\n<\/td>\n Ing\u00e9nieur<\/p>\n Adjoint technique<\/p>\n<\/td>\n CHU de Poitiers<\/p>\n Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n BOILDIEU Nad\u00e8ge<\/p>\n<\/td>\n Adjoint technique<\/p>\n<\/td>\n Universit\u00e9 de Poitiers<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n CHAUVELON Fran\u00e7oise<\/p>\n<\/td>\n Technicienne<\/p>\n<\/td>\n CHU de Poitiers<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n JACQUART Ma\u00eft\u00e9<\/p>\n<\/td>\n Technicienne<\/p>\n<\/td>\n CHU de Poitiers<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n JOFFRION Sandrine<\/p>\n<\/td>\n Technicienne<\/p>\n<\/td>\n CHU de Poitiers<\/p>\n<\/td>\n Non<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Liste des doctorants (au 1\/01\/2010)<\/strong><\/span><\/p>\n Directeur de th\u00e8se<\/p>\n<\/td>\n Etablissement d’inscription Ecole doctorale<\/p>\n<\/td>\n<\/tr>\n CODAS Ricardo<\/p>\n<\/td>\n BADET Lionel \/ HAUET Thierry<\/p>\n<\/td>\n Bio-sant\u00e9 Poitiers<\/p>\n<\/td>\n<\/tr>\n CHAILLOU Matthieu<\/p>\n<\/td>\n MAIXENT Jean-Michel<\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers\/CIFRE<\/p>\n<\/td>\n<\/tr>\n FARES Mourad<\/p>\n<\/td>\n MAIXENT Jean-Michel<\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers \/CIFRE<\/p>\n<\/td>\n<\/tr>\n GUILLAUD Fran\u00e7ois<\/p>\n<\/td>\n MAUCO G\u00e9rard \/ HANNAERT Patrick<\/p>\n<\/td>\n Bio-sant\u00e9 Poitiers<\/p>\n<\/td>\n<\/tr>\n GIRAUD S\u00e9bastien<\/p>\n<\/td>\n HAUET Thierry<\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers (CIFRE)<\/p>\n<\/td>\n<\/tr>\n ROSSARD Ludivine<\/p>\n<\/td>\n HAUET Thierry<\/span><\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers<\/span><\/p>\n<\/td>\n<\/tr>\n MALLET Vanessa<\/p>\n<\/td>\n HAUET Thierry<\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Th\u00e9matiques de recherche (au 1\/01\/2010)<\/strong><\/span><\/p>\n Les recherches effectu\u00e9es au sein de l’U1082 de l’Inserm rel\u00e8vent du champ de la transplantation r\u00e9nale. Nous nous int\u00e9ressons essentiellement \u00e0 la compr\u00e9hension du d\u00e9roulement et des cons\u00e9quences de l’isch\u00e9mie-reperfusion (IR) et \u00e0 la lutte contre ses cons\u00e9quences dans l’optique d’am\u00e9liorer les conditions de greffes, d’\u00e9largir le champ des organes utilisables et, in fine, de proposer de nouveaux protocoles. Cette s\u00e9quence IR est une partie intrins\u00e8que du processus des transplantations d’organes, li\u00e9e \u00e0 la conservation dans des solutions ad\u00e9quates, \u00e0 4\u00b0C, ce qui entra\u00eene une phase d’anoxie hypothermique, suivie d’une p\u00e9riode de r\u00e9-oxyg\u00e9nation \u00e0 temp\u00e9rature corporelle apr\u00e8s la r\u00e9-implantation. Cependant, ce mod\u00e8le th\u00e9orique et simplifi\u00e9 d’isch\u00e9mie hypothermique est en fait compl\u00e9t\u00e9 par des p\u00e9riodes br\u00e8ves d’isch\u00e9mie \u00e0 temp\u00e9rature progressivement plus \u00e9lev\u00e9e lors du r\u00e9chauffement de l’organe transplant\u00e9, pendant la r\u00e9alisation des anastomoses ou, parfois plus longues, avant l’ex\u00e9r\u00e8se du greffon, \u00e0 temp\u00e9rature corporelle, dans le cas ou la stabilit\u00e9 h\u00e9modynamique du donneur n’est plus assur\u00e9e ou, \u00e9ventuellement, chez les donneurs \u00e0 c\u0153ur arr\u00eat\u00e9.<\/p>\n La transplantation r\u00e9nale est la th\u00e9rapeutique de choix de l’insuffisance r\u00e9nale chronique terminale mais elle se heurte \u00e0 plusieurs obstacles pratiques li\u00e9s essentiellement \u00e0 la p\u00e9nurie d’organes \u00e0 transplanter. Cet \u00e9tat de fait induit la n\u00e9cessit\u00e9 de mettre au point de nouveaux protocoles de pr\u00e9l\u00e8vement, conservation et suivi post-op\u00e9ratoire : pr\u00e9l\u00e8vements chez des donneurs \u00e2g\u00e9s, chez des donneurs \u00e0 coeur arr\u00eat\u00e9, facteurs aggravant les l\u00e9sions d’isch\u00e9mie-reperfusion.<\/p>\n Notre approche associe l’exp\u00e9rimentation pr\u00e9-clinique sur un mod\u00e8le proche de l’homme : le porc Large White et l’exp\u00e9rimentation in vitro et ex vivo. Nous testons ainsi diff\u00e9rents protocoles de conservation avec des collo\u00efdes (poly-\u00e9thyl\u00e8ne glycols), des anti-coagulants et diverses autres mol\u00e9cules (confidentielles, brevets d\u00e9pos\u00e9s ou en cours d’instruction). In vitro et ex vivo, nous nous int\u00e9ressons aux m\u00e9canismes de transmission du signal et \u00e0 l’expression g\u00e9nique\/prot\u00e9ique mis en place sur des mod\u00e8les cellulaires pertinents et dans des biopsies provenant d’animaux trait\u00e9s.<\/p>\n Diff\u00e9rentes \u00e9tudes cliniques sont en cours de r\u00e9alisation (spectroscopie RMN des fluides, devenir des greffons chez l’homme).<\/p>\n Principaux r\u00e9sultats et leur impact sur la prise en charge du patient :<\/p>\n Publications scientifiques (de 2006 \u00e0 2010)<\/strong><\/span><\/p>\n 1.\u00a0Favreau F, Zhu XY, Krier JD, Lin J, Textor SC, Lerman LO. \u00ab\u00a0Revascularization of swine renal artery stenosis improves renal function but not the changes in vascular structure.\u00a0\u00bb Kidney Int. 2010 (sous presse)<\/p>\n 2.\u00a0Guillaud F, Hannaert P, \u00ab\u00a0A computational model of the circulating renin-angiotensin system and blood pressure regulation.\u00a0\u00bb Acta Biotheor. 2010 (sous presse)<\/p>\n 3.\u00a0Brunet B, Hauet T, Hebrard W, Papet Y, Mauco G, Mura P. \u00ab\u00a0Post-mortem redistribution of THC in the pig\u00a0\u00bb Int. J. Legal Med. 2010 (sous presse)<\/p>\n 4.\u00a0Robert R, Guilhot J, Longeart PL, Jacob JP, Mauco G, Hauet T, Seguin F. \u00ab\u00a0A pair analysis of the delayed graft function in kidney recipient: the critical role of the donor\u00a0\u00bb. J. Crit. Care 2010 (sous presse)<\/p>\n 5.\u00a0Thuillier R, Favreau F, Celhay O,\u00a0 Macchi L, Milin S, Hauet T \u00ab\u00a0Thrombin inhibition during kidney ischemia-reperfusion reduces chronic graft inflammation and tubular atrophy\u00a0\u00bb Transplantation 2010 (sous presse)<\/p>\n 6.\u00a0Favreau F, Thuillier R, Cau J, Milin S, Manguy E, Mauco G, Zhu X, Lerman LO, Hauet T. \u00ab\u00a0Anti-thrombin Therapy During Warm Ischemia and Cold Preservation Prevents Chronic Kidney Graft Fibrosis in a DCD Model.\u00a0\u00bb Am. J. Transplant. 10(1): 30-39. 2010<\/p>\n 7.\u00a0Thuillier R, Tillement JP, Hauet T. \u00ab\u00a0Renal Protective Effect of Metabolic Therapy in Patients with Coronary Artery Disease and Diabetes: From Bench to Bed Side.\u00a0\u00bb Curr. pharm. Design 15(8): 863-882. 2009<\/p>\n 8.\u00a0Jayle C, Faure JP, Thuillier R, Goujon JM, Richer JP, Hauet T. \u00ab\u00a0Influence of nephron mass and a phosphorylated 38 mitogen-activated protein kinase inhibitor on the development of early and long-term injury after renal warm ischaemia.\u00a0\u00bb Br. J. Surg. 96(7): 799-808. 2009<\/p>\n 9.\u00a0Giraud S, Thuillier R, Belliard A, Hebrard W, Nadeau C, Milin S, Goujon JM, Manguy E, Mauco G, Hauet T, Macchi L. \u00ab\u00a0Direct Thrombin Inhibitor Prevents Delayed Graft Function in a Porcine Model of Renal Transplantation.\u00a0\u00bb Transplantation 87(11): 1636-1644. 2009<\/p>\n 10.\u00a0Favreau F, Rossard L, Zhang K, Desurmont T, Manguy E, Belliard A, Fabre S, Liu J, Han ZQ, Thuillier R, Papadopoulos V, Hauet T. \u00ab\u00a0Expression and modulation of translocator protein and its partners by hypoxia reoxygenation or ischemia and reperfusion in porcine renal models.\u00a0\u00bb Am. J. physiol.-Renal physiol. 297(1): F177-F190. 2009<\/p>\n 11.\u00a0Dutheil D, Underhaug Gjerde A, Petit-Paris I, Mauco G, Holmsen H. \u00ab\u00a0Polyethylene glycols interact with membrane glycerophospholipids: is this part of their mechanism for hypothermic graft protection?\u00a0\u00bb J. Chem. Biol. Mar;2(1):39-49. 2009<\/p>\n 12.\u00a0Cau J, Favreau F, Zhang K, Febrer G, Regnault de la Motte G, Ricco JB, Goujon JM, Hauet T. \u00ab\u00a0FR167653 improves renal recovery and decreases inflammation and fibrosis after renal ischemia reperfusion injury.\u00a0\u00bb J. Vasc. Surg. 49(3): 728-740. 2009<\/p>\n 13.\u00a0Hauet T, Eugene M. \u00ab\u00a0A new approach in organ preservation: potential role of new polymers.\u00a0\u00bb Kidney Int. 74(8): 998-1003. 2008<\/p>\n 14.\u00a0Doucet C, Milin S, Favreau F, Desurmont T, Manguy E, Hebrard W, Yamamoto Y, Mauco G, Eugene M, Papadopoulos V, Hauet T, Goujon JM. \u00ab\u00a0A p38 mitogen-activated protein kinase inhibitor protects against renal damage in a non-heart-beating donor model.\u00a0\u00bb Am. J. physiol.-Renal. physiol. 295(1): F179-F191. 2008<\/p>\n 15.\u00a0Belliard A, Mauco G, Bonnet ML, Hauet T, Macchi L. \u00ab\u00a0Melagatran prevents tissue factor expression in human platelets-monocyte heterotopic complexes.\u00a0\u00bb Cell. Mol. Biol. 54: 1077-1082. 2008<\/p>\n 16.\u00a0Pierre SV, Lesnik P, Moreau M, Bonello L, Droy-Lefaix MT, Sennoune S, Duran MJ, Pressley TA, Sampol J, Chapman J, Maixent JM. \u00ab\u00a0The standardized Ginkgo biloba extract Egb-761 protects vascular endothelium exposed to oxidized low density lipoproteins.\u00a0\u00bbCell. Mol. Biol. (Noisy-le-grand). Oct 26;54 Suppl:OL1032-42. 2008<\/p>\n 17.\u00a0Kalifa J, Maixent JM, Chalvidan T, Dalmasso C, Colin D, Cozma D, Laurent P, Deharo JC, Djiane P, Cozzone P, Bernard M. \u00ab\u00a0Energetic metabolism during acute stretch-related atrial fibrillation.\u00a0\u00bb Mol. Cell. Biochem. Oct;317(1-2):69-75. 2008<\/p>\n 18.\u00a0Thomas SR, Baconnier P,\u00a0 Fontecave J, Francoise JP, Guillaud F, Hannaert P,\u00a0 Hernandez A, Le Rolle V,\u00a0 Maziere P, Tahi F, White RJ (alphabetical order after SR Thomas). \u00ab\u00a0SAphIR: a physiome core model of body fluid homeostasis and blood pressure regulation.\u00a0\u00bbphilos. Transact. A Math. phys. Eng. Sci. 366(1878):\u00a0 3175-97 2008<\/p>\n 19.\u00a0Guillaud F, Hannaert P. \u00ab\u00a0Dynamic simulation of mitochondrial respiration and oxidative phosphorylation: comparison with experimental results.\u00a0\u00bb Acta Biotheor.\u00a0 56(1-2): 157-72 2008.<\/p>\n 20.\u00a0 Rigoard P, Tartarin F, Buffenoir K, Chaillou M, Fares M, D’Houtaud S, Wager M, Giot JP, Quellard N, Fernandez B, Lapierre F, Maixent JM. \u00ab\u00a0The Na, K-ATPase alpha3-isoform specifically localizes in the Schmidt-Lanterman incisures of human nerve. Cell. Mol. Biol.\u00a0\u00bb (Noisy-le-grand). Nov 19;53 Suppl:OL1003-9. 2007<\/p>\n 21.\u00a0Thomas SR, Abdulhay E, Baconnier P, Fontecave J, Francoise JP, Guillaud F, Hannaert P, Hernandez A, Le Rolle V, Maziere P, Tahi F, Zehraoui F (alphabetical order after SR Thomas). \u00ab\u00a0SAphIR – a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis.\u00a0\u00bbIEEE Eng. Med. Biol. Soc. 1:6648-51 2007<\/p>\n 22.\u00a0El Aoufi S, Gendre P, Sennoune SR, Rigoard P, Maixent JM, Griene L. \u00ab\u00a0A high calorie diet induces type 2 diabetes in the desert sand rat (Psammomys obesus). \u00ab\u00a0Cell. Mol. Biol. (Noisy-le-grand). Jul 21;53 Suppl:OL943-53. 2007<\/p>\n 23.\u00a0Kalifa J, Bernard M, Gout B, Bril A, Cozma D, Laurent P, Chalvidan T, Deharo JC, Djiane P, Cozzone P, Maixent JM. \u00ab\u00a0Anti-arrhythmic effects of I (Na), I (Kr) and combined I (Kr)-I (CaL) blockade in an experimental model of acute stretch-related atrial fibrillation.\u00a0\u00bb Cardiovasc. Drugs Ther. Feb;21(1):47-53. 2007<\/p>\n 24.\u00a0Jayle C, Favreau F, Zhang KQ, Doucet C, Goujon JM, Hebrard W, Carretier M, Eugene M, Mauco G, Tillement JP, Hauet T. \u00ab\u00a0Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model.\u00a0\u00bb Am. J. physiol.-Renal physiol. 292(3): F1082-F1093. 2007<\/p>\n 25.\u00a0Doucet C, Zhang K, Desurmont T, Hebrard W, Scepi M, Nadeau C, Cau J, Leyre P, Febrer G, Carretier M, Richer JP, Papadopoulos V, Hauet T, Burucoa C, Goujon JM. \u00ab\u00a0Influence of warm ischemia time on peripheral-type benzodiazepine receptor: A new aspect of the role of mitochondria.\u00a0\u00bb Nephron Exp. Nephrol 107(1): E1-E11. 2007<\/p>\n 26.\u00a0Giraud S, Claire B, Eugene M, Debre P, Richard F, Barrou B. \u00ab\u00a0\u00a0\u00bbA new preservation solution increases islet yield and reduces graft immunogenicity in pancreatic islet transplantation.\u00a0\u00bb (vol 83, pg 1397, 2007).\u00a0\u00bb Transplantation 84(4): 561-561. 2007<\/p>\n 27.\u00a0Zhang KQ, Desurmont T, Goujon JM, Favreau F, Cau J, Deretz S, Mauco G, Carretier M, Papadopoulos V, Hauet T. \u00ab\u00a0Modulation of peripheral-type benzodiazepine receptor during ischemia reperfusion injury in a pig kidney model: A new partner of leukemia inhibitory factor in tubular regeneration.\u00a0\u00bb J. Am. Coll. Surg. 203(3): 353-364. 2006<\/p>\n 28.\u00a0Zhang KQ, Demeure O, Belliard A, Goujon JM, Favreau F, Desurmont T, Mauco G, Barriere M, Carretier M, Milan D, Papadopoulos V, Hauet T. \u00ab\u00a0Cloning, sequencing, and chromosomal localization of pig peripheral benzodiazepine receptor: three different forms produced by alternative splicing.\u00a0\u00bb Mamm. Genome 17(10): 1050-1062. 2006<\/p>\n 29.\u00a0Badet L, Eugene M,\u00a0 Hauet T, Barrou B. \u00ab\u00a0The use of preservation solutions in renal transplantation.\u00a0\u00bb Prog. Urol. 16:25-31. 2006<\/p>\n 30.\u00a0Neuzillet Y, Giraud S, Lagorce L, Eugene M, Richard F, Debre P, Barrou B. \u00ab\u00a0In vivo comparison of preservation of murine islets of Langerhans.\u00a0\u00bb Prog. Urol. 16(1): 73-77. 2006<\/p>\n 31.\u00a0Jayle C, Milinkevitch S, Favreau F, Doucet C, Richer JP, Deretz S, Mauco G, Rabb H, Hauet T. \u00ab\u00a0Protective role of selectin ligand inhibition in a large animal model of kidney ischemia-reperfusion injury.\u00a0\u00bb Kidney Int. 69(10): 1749-1755. 2006<\/p>\n 32.\u00a0Godet C, Goujon JM, Petit I, Lecron JC, Hauet T, Mauco G, Carretier M, Robert R. \u00ab\u00a0Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats.\u00a0\u00bb Shock 25(4): 384-388. 2006<\/p>\n 33.\u00a0Dutheil D, Rioja-Pastor I, Tallineau C, Goujon JM, Hauet T, Mauco G, Petit-Paris I. \u00ab\u00a0Protective effect of PEG 35000 Da on renal cells: Paradoxical activation of JNK signaling pathway during cold storage.\u00a0\u00bb Am. J. Transplant. 6(7): 1529-1540. 2006<\/p>\n 34.\u00a0Genesca M, Ivorra A, Sola A, Palacios L, Goujon JM, Hauet T, Villa R, Aguilo J, Hotter G. \u00ab\u00a0Electrical bioimpedance measurement during hypothermic rat kidney preservation for assessing ischemic injury.\u00a0\u00bb Biosens. Bioelectron. 20(9): 1866-1871. 2005<\/p>\n 35.\u00a0Hauet T, Yao ZX, Bose HS, Wall CT, Han Z, Li W, Hales DB, Miller WL, Culty M, Papadopoulos V. \u00ab\u00a0Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria.\u00a0\u00bb Mol. Endocrinol. Feb;19(2):540-54. 2005<\/p>\n 36.\u00a0Giraud S, Hauet T, Eugene M, Mauco G, Barrou B. \u00ab\u00a0A New Preservation Solution (SCOT 15) Improves the islet Isolation process from pancreata of Non-Heart-Beating Donors: A Murine Model.\u00a0\u00bb Transplant. Proc. 41(8): 3293-3295. 2009\u00a0\u00a0 8th Annual Congress of the French-Speaking-Society-of-Transplantation OCT, 2008 Quebec City, CANADA<\/p>\n 37.\u00a0Codas R, Badet L, Eugene M, Giraud S, Thuiller R, Hauet T. \u00ab\u00a0Evaluation of pulsatile Perfusion Machine RM3 for Kidney Preservation in a Swine Model of Renal Autotransplantation.\u00a0\u00bb Transplant. Proc. 41(8): 3296-3298. 2009\u00a0 8th Annual Congress of the French-Speaking-Society-of-Transplantation OCT, 2008 Quebec City, CANADA<\/p>\n 38.\u00a0Neuzillet Y, Giraud S, Lagorce L, Eugene M, Debre P, Richard F, Barrou B. \u00ab\u00a0Effects of the molecular weight of peg molecules (8, 20 and 35 KDA) on cell function and allograft survival prolongation in pancreatic islets transplantation.\u00a0\u00bb Transplant. Proc. 38(7): 2354-2355. 2006\u00a0\u00a0 5th Annual Conference of the French-Speaking-Society-of-Transplantation DEC 07-10, 2005 Tours, FRANCE<\/p>\n 39.\u00a0Brunet B, Doucet C, Venisse N, Hauet T, Hebrard W, Papet Y, Mauco G, Mura P. \u00ab\u00a0Validation of Large White Pig as an animal model for the study of cannabinoids metabolism: Application to the study of THC distribution in tissues.\u00a0\u00bb Forensic Sci.Int. 161(2-3): 169-174. 2006\u00a0\u00a0 43rd International Conference of the International-Association-of-Forensic-Toxicologists (TIAFT) AUG 29-SEP 02, 2005 Seoul, SOUTH KOREA<\/p>\n 40.\u00a0Rigoard P, Buffenoir K, Chaillou M, Fares M, Da Costa L, Boildieu N, Seguin F, Lapierre F, Maixent JM, Bauche S, Koenig J, Hanta\u00ef D. \u00ab\u00a0Morphological study of CNS lesions and the consequences on rat neuromuscular junction and peripheral nerve using confocal laser scanning microscopy and Koelle’s technique. \u00ab\u00a0Neurochirurgie. Mar;55 Suppl 1:S110-23. 2009<\/p>\n 41.\u00a0Rigoard P, Buffenoir K, Bauche S, Fares M, Koenig J, Hanta\u00ef D, Giot JP, Seguin F, Huze C, Schaeffer L, Maixent JM. \u00ab\u00a0Tools and techniques dedicated to neuromuscular junction observation.\u00a0\u00bb Neurochirurgie. Mar;55 Suppl 1:S43-8. 2009<\/p>\n 42.\u00a0Rigoard P, Bauche S, Buffenoir K, Da Costa L, Boildieu N, Seguin F, Koenig J, Lapierre F, Maixent JM. \u00ab\u00a0Pathophysiological, molecular and metabolic changes at the neuromuscular junction and the peripheral nerve after central nervous system lesions in humans.\u00a0\u00bb Neurochirurgie. Mar;55 Suppl 1:S135-47. 2009<\/p>\n 43.\u00a0Rigoard P, Buffenoir K, Fares M, Chaillou M, Da Costa L, Boildieu N, Seguin F, Huze C, Schaeffer L, Lapierre F, Maixent JM. \u00ab\u00a0Toward a metabolic approach of the central pattern generator concept in a spinal rat model.\u00a0\u00bb Neurochirurgie. Mar;55 Suppl 1:S124-34. 2009<\/p>\n 44.\u00a0Rigoard S, Wager M, Buffenoir K, Bauche S, Giot JP, Maixent JM, Rigoard P. Major mechanisms involved in the synaptic transmission of the neuromuscular apparatus. Neurochirurgie. Mar;55 Suppl 1:S22-33. Review. 2009<\/p>\n 45.\u00a0Rigoard P,\u00a0 Chaillou M, Fares M, Sottejeau Y, Giot JP, Honfo-Ga C, Rohan J, Lapierre F, Maixent JM. \u00ab\u00a0Energetic applications: Na+\/K+-ATPase and neuromuscular transmission.\u00a0\u00bb Neurochirurgie. Mar;55 Suppl 1:S92-103. Review. 2009.<\/p>\n","protected":false},"excerpt":{"rendered":" LES MISSIONS DE RECHERCHE La recherche fondamentale en biologie au CHU de Poitiers, c’est : Inserm ERM 0324 \u00abIsch\u00e9mie-reperfusion en transplantation r\u00e9nale\u00a0\u00bb, \u00a0directeur\u00a0 : Pr G\u00e9rard MAUCO EA 3805 \u00ab\u00a0Syndromes my\u00e9loprolif\u00e9ratifs\u00a0: cytog\u00e9n\u00e9tique, signalisation, cycle cellulaire et r\u00e9ponse immunitaire\u00a0\u00bb, \u00a0directeur\u00a0 : Pr Ali TURHAN EA 4331 \u00ab\u00a0Inflammation, tissus \u00e9pith\u00e9liaux et cytokines \u00bb, directeur\u00a0 : Pr Jean-Claude […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\n\n\n
\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/td>\n<\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n
\n Nom, pr\u00e9nom<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n