Basic research in biology at the Poitiers CHU consists in:<\/p>\n
Director: Pr G\u00e9rard MAUCO<\/strong><\/span><\/p>\n Staff (as of 1\/01\/2010)<\/span><\/strong><\/p>\n Main employer(s)<\/p>\n<\/td>\n HDR (research director) (yes\/no)<\/p>\n<\/td>\n<\/tr>\n EUGENE Michel<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n<\/td>\n FAVREAU Fr\u00e9d\u00e9ric<\/p>\n<\/td>\n university lecturer -ph<\/span><\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n GOUJON Jean-Michel<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n HADJADJ Samy<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n HAUET Thierry<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n LEVILLAIN Pierre<\/p>\n MAIXENT Jean-Michel<\/p>\n<\/td>\n pu-ph<\/p>\n pu<\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n University of Poitiers<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n MAUCO G\u00e9rard<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n RICHER Jean-Pierre<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n ROBERT Ren\u00e9<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n SEGUIN Fran\u00e7ois<\/p>\n<\/td>\n pu<\/p>\n<\/td>\n University of Poitiers<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n TOUCHARD Guy<\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n CHU and University of Poitiers<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n BADET Lionel<\/span><\/p>\n<\/td>\n pu-ph<\/span><\/p>\n<\/td>\n Civil hospices of Lyon<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n BARROU Beno\u00eet<\/span><\/p>\n<\/td>\n pu-ph<\/p>\n<\/td>\n AP-HP (Paris hospitals)<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n HANNAERT Patrick<\/p>\n<\/td>\n CR1 CNRS<\/span><\/p>\n<\/td>\n CNRS<\/p>\n<\/td>\n Yes<\/p>\n<\/td>\n<\/tr>\n CAU J\u00e9r\u00f4me<\/p>\n<\/td>\n ph<\/p>\n<\/td>\n CHU of Poitiers<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n JAYLE Christophe<\/p>\n<\/td>\n ph<\/p>\n<\/td>\n CHU of Poitiers<\/p>\n<\/td>\n no<\/p>\n<\/td>\n<\/tr>\n CHATAURET Nicolas<\/p>\n<\/td>\n Post-PhD<\/p>\n<\/td>\n Contractual NRA<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n GIRAUD S\u00e9bastien<\/p>\n<\/td>\n CHU of Poitiers<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n THUILLIER Raphael<\/p>\n<\/td>\n Engineer<\/p>\n<\/td>\n CHU of Poitiers<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n FERNANDEZ B\u00e9atrice<\/p>\n<\/td>\n Engineer<\/p>\n<\/td>\n CHU of Poitiers<\/p>\n<\/td>\n QUELLARD Nathalie<\/p>\n AMETEAU Virginie<\/p>\n<\/td>\n Engineer<\/p>\n Technical assistant<\/p>\n<\/td>\n CHU of Poitiers<\/p>\n University of Poitiers<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n BOILDIEU Nad\u00e8ge<\/p>\n<\/td>\n University of Poitiers<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n CHAUVELON Fran\u00e7oise<\/p>\n<\/td>\n Technician<\/p>\n<\/td>\n CHU of Poitiers<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n JACQUART Ma\u00eft\u00e9<\/p>\n<\/td>\n Technician<\/p>\n<\/td>\n CHU of Poitiers<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n JOFFRION Sandrine<\/p>\n<\/td>\n Technician<\/p>\n<\/td>\n CHU of Poitiers<\/p>\n<\/td>\n No<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n PhD candidates (as of 1\/01\/2010)<\/strong><\/span><\/p>\n Doctoral school of registration<\/p>\n<\/td>\n<\/tr>\n CODAS Ricardo<\/p>\n<\/td>\n BADET Lionel \/ HAUET Thierry<\/p>\n<\/td>\n Bio-sant\u00e9 Poitiers<\/p>\n<\/td>\n<\/tr>\n CHAILLOU Matthieu<\/p>\n<\/td>\n MAIXENT Jean-Michel<\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers\/CIFRE<\/p>\n<\/td>\n<\/tr>\n FARES Mourad<\/p>\n<\/td>\n MAIXENT Jean-Michel<\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers \/CIFRE<\/p>\n<\/td>\n<\/tr>\n GUILLAUD Fran\u00e7ois<\/p>\n<\/td>\n MAUCO G\u00e9rard \/ HANNAERT Patrick<\/p>\n<\/td>\n Bio-sant\u00e9 Poitiers<\/p>\n<\/td>\n<\/tr>\n GIRAUD S\u00e9bastien<\/p>\n<\/td>\n HAUET Thierry<\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers (CIFRE)<\/p>\n<\/td>\n<\/tr>\n ROSSARD Ludivine<\/p>\n<\/td>\n HAUET Thierry<\/span><\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers<\/span><\/p>\n<\/td>\n<\/tr>\n MALLET Vanessa<\/p>\n<\/td>\n HAUET Thierry<\/p>\n<\/td>\n Bio-Sant\u00e9 Poitiers<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Research themes (as of 1\/01\/2010)<\/strong><\/span><\/p>\n The research pursued in Inserm U1082 concerns renal transplantation. We are essentially interested in the process and consequences of ischemia-reperfusion (IR) and the mitigation of these consequences in view of improving transplantation conditions, of widening the field of usable organs and, in the end, of proposing new protocols. This IR sequence is an intrinsic component of the organ transplantation process, and it is associated with conservation in adequate solutions, at 4\u00b0C, which brings about a phase of hypothermic anoxia, followed by a period of reoxygenation at body temperature after reimplantation. However, this theoretical and simplified model of hypothermic ischemia is in fact completed by brief periods of ischemia at a progressively higher temperature during reheating of the transplanted organ, during anastomoses or, possibly for a longer lapse of time, before exeresis of the graft, at body temperature in cases where the hemodynamic stability of the donor is not guaranteed or, in extreme cases, in donors whose heart has stopped beating.<\/p>\n While renal transplantation is the preferred therapy in terminal chronic renal failure, it has encountered many practical obstacles connected with a penury of organs to be transplanted.This situation entails a need to develop protocols for retrieval, conservation, and post-operative monitoring: retrieval from aged donors and from donors whose heart has stopped beating, factors contributing to the aggravation of ischemia-reperfusion lesions.<\/p>\n Our approach associates preclinical experimentation on a model relatively close to the human being, namely the Large White pig, with in vitro and ex vivo experimentation. We also test different protocols of conservation with colloids (polyethylene glycols), anticoagulants and a number of other molecules (confidential, patent issued or pending). \u00a0 In vitro and ex vivo, we are interested in the transmission mechanisms of the signal and the the gene\/protein expression put into place on relevant cell models and in biopsies from the treated animals.<\/p>\n Different clinical studies are ongoing: NMR fluid spectroscopy, evolution of grafts in humans…<\/p>\n Principal results and their impact on treatment of patients:<\/p>\n Scientific publications \u00a0(from 2006 to 2010)<\/strong><\/span><\/p>\n 1.\u00a0Favreau F, Zhu XY, Krier JD, Lin J, Textor SC, Lerman LO. \u00ab\u00a0Revascularization of swine renal artery stenosis improves renal function but not the changes in vascular structure.\u00a0\u00bb Kidney Int. 2010 (sous presse)<\/p>\n 2.\u00a0Guillaud F, Hannaert P, \u00ab\u00a0A computational model of the circulating renin-angiotensin system and blood pressure regulation.\u00a0\u00bb Acta Biotheor. 2010 (sous presse)<\/p>\n 3.\u00a0Brunet B, Hauet T, Hebrard W, Papet Y, Mauco G, Mura P. \u00ab\u00a0Post-mortem redistribution of THC in the pig\u00a0\u00bb Int. J. Legal Med. 2010 (sous presse)<\/p>\n 4.\u00a0Robert R, Guilhot J, Longeart PL, Jacob JP, Mauco G, Hauet T, Seguin F. \u00ab\u00a0A pair analysis of the delayed graft function in kidney recipient: the critical role of the donor\u00a0\u00bb. J. Crit. Care 2010 (sous presse)<\/p>\n 5.\u00a0Thuillier R, Favreau F, Celhay O,\u00a0 Macchi L, Milin S, Hauet T \u00ab\u00a0Thrombin inhibition during kidney ischemia-reperfusion reduces chronic graft inflammation and tubular atrophy\u00a0\u00bb Transplantation 2010 (sous presse)<\/p>\n 6.\u00a0Favreau F, Thuillier R, Cau J, Milin S, Manguy E, Mauco G, Zhu X, Lerman LO, Hauet T. \u00ab\u00a0Anti-thrombin Therapy During Warm Ischemia and Cold Preservation Prevents Chronic Kidney Graft Fibrosis in a DCD Model.\u00a0\u00bb Am. J. Transplant. 10(1): 30-39. 2010<\/p>\n 7.\u00a0Thuillier R, Tillement JP, Hauet T. \u00ab\u00a0Renal Protective Effect of Metabolic Therapy in Patients with Coronary Artery Disease and Diabetes: From Bench to Bed Side.\u00a0\u00bb Curr. pharm. Design 15(8): 863-882. 2009<\/p>\n 8.\u00a0Jayle C, Faure JP, Thuillier R, Goujon JM, Richer JP, Hauet T. \u00ab\u00a0Influence of nephron mass and a phosphorylated 38 mitogen-activated protein kinase inhibitor on the development of early and long-term injury after renal warm ischaemia.\u00a0\u00bb Br. J. Surg. 96(7): 799-808. 2009<\/p>\n 9.\u00a0Giraud S, Thuillier R, Belliard A, Hebrard W, Nadeau C, Milin S, Goujon JM, Manguy E, Mauco G, Hauet T, Macchi L. \u00ab\u00a0Direct Thrombin Inhibitor Prevents Delayed Graft Function in a Porcine Model of Renal Transplantation.\u00a0\u00bb Transplantation 87(11): 1636-1644. 2009<\/p>\n 10.\u00a0Favreau F, Rossard L, Zhang K, Desurmont T, Manguy E, Belliard A, Fabre S, Liu J, Han ZQ, Thuillier R, Papadopoulos V, Hauet T. \u00ab\u00a0Expression and modulation of translocator protein and its partners by hypoxia reoxygenation or ischemia and reperfusion in porcine renal models.\u00a0\u00bb Am. J. physiol.-Renal physiol. 297(1): F177-F190. 2009<\/p>\n 11.\u00a0Dutheil D, Underhaug Gjerde A, Petit-Paris I, Mauco G, Holmsen H. \u00ab\u00a0Polyethylene glycols interact with membrane glycerophospholipids: is this part of their mechanism for hypothermic graft protection?\u00a0\u00bb J. Chem. Biol. Mar;2(1):39-49. 2009<\/p>\n 12.\u00a0Cau J, Favreau F, Zhang K, Febrer G, Regnault de la Motte G, Ricco JB, Goujon JM, Hauet T. \u00ab\u00a0FR167653 improves renal recovery and decreases inflammation and fibrosis after renal ischemia reperfusion injury.\u00a0\u00bb J. Vasc. Surg. 49(3): 728-740. 2009<\/p>\n 13.\u00a0Hauet T, Eugene M. \u00ab\u00a0A new approach in organ preservation: potential role of new polymers.\u00a0\u00bb Kidney Int. 74(8): 998-1003. 2008<\/p>\n 14.\u00a0Doucet C, Milin S, Favreau F, Desurmont T, Manguy E, Hebrard W, Yamamoto Y, Mauco G, Eugene M, Papadopoulos V, Hauet T, Goujon JM. \u00ab\u00a0A p38 mitogen-activated protein kinase inhibitor protects against renal damage in a non-heart-beating donor model.\u00a0\u00bb Am. J. physiol.-Renal. physiol. 295(1): F179-F191. 2008<\/p>\n 15.\u00a0Belliard A, Mauco G, Bonnet ML, Hauet T, Macchi L. \u00ab\u00a0Melagatran prevents tissue factor expression in human platelets-monocyte heterotopic complexes.\u00a0\u00bb Cell. Mol. Biol. 54: 1077-1082. 2008<\/p>\n 16.\u00a0Pierre SV, Lesnik P, Moreau M, Bonello L, Droy-Lefaix MT, Sennoune S, Duran MJ, Pressley TA, Sampol J, Chapman J, Maixent JM. \u00ab\u00a0The standardized Ginkgo biloba extract Egb-761 protects vascular endothelium exposed to oxidized low density lipoproteins.\u00a0\u00bbCell. Mol. Biol. (Noisy-le-grand). Oct 26;54 Suppl:OL1032-42. 2008<\/p>\n 17.\u00a0Kalifa J, Maixent JM, Chalvidan T, Dalmasso C, Colin D, Cozma D, Laurent P, Deharo JC, Djiane P, Cozzone P, Bernard M. \u00ab\u00a0Energetic metabolism during acute stretch-related atrial fibrillation.\u00a0\u00bb Mol. Cell. Biochem. Oct;317(1-2):69-75. 2008<\/p>\n 18.\u00a0Thomas SR, Baconnier P,\u00a0 Fontecave J, Francoise JP, Guillaud F, Hannaert P,\u00a0 Hernandez A, Le Rolle V,\u00a0 Maziere P, Tahi F, White RJ (alphabetical order after SR Thomas). \u00ab\u00a0SAphIR: a physiome core model of body fluid homeostasis and blood pressure regulation.\u00a0\u00bbphilos. Transact. A Math. phys. Eng. Sci. 366(1878):\u00a0 3175-97 2008<\/p>\n 19.\u00a0Guillaud F, Hannaert P. \u00ab\u00a0Dynamic simulation of mitochondrial respiration and oxidative phosphorylation: comparison with experimental results.\u00a0\u00bb Acta Biotheor.\u00a0 56(1-2): 157-72 2008.<\/p>\n 20.\u00a0 Rigoard P, Tartarin F, Buffenoir K, Chaillou M, Fares M, D’Houtaud S, Wager M, Giot JP, Quellard N, Fernandez B, Lapierre F, Maixent JM. \u00ab\u00a0The Na, K-ATPase alpha3-isoform specifically localizes in the Schmidt-Lanterman incisures of human nerve. Cell. Mol. Biol.\u00a0\u00bb (Noisy-le-grand). Nov 19;53 Suppl:OL1003-9. 2007<\/p>\n 21.\u00a0Thomas SR, Abdulhay E, Baconnier P, Fontecave J, Francoise JP, Guillaud F, Hannaert P, Hernandez A, Le Rolle V, Maziere P, Tahi F, Zehraoui F (alphabetical order after SR Thomas). \u00ab\u00a0SAphIR – a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis.\u00a0\u00bbIEEE Eng. Med. Biol. Soc. 1:6648-51 2007<\/p>\n 22.\u00a0El Aoufi S, Gendre P, Sennoune SR, Rigoard P, Maixent JM, Griene L. \u00ab\u00a0A high calorie diet induces type 2 diabetes in the desert sand rat (Psammomys obesus). \u00ab\u00a0Cell. Mol. Biol. (Noisy-le-grand). Jul 21;53 Suppl:OL943-53. 2007<\/p>\n 23.\u00a0Kalifa J, Bernard M, Gout B, Bril A, Cozma D, Laurent P, Chalvidan T, Deharo JC, Djiane P, Cozzone P, Maixent JM. \u00ab\u00a0Anti-arrhythmic effects of I (Na), I (Kr) and combined I (Kr)-I (CaL) blockade in an experimental model of acute stretch-related atrial fibrillation.\u00a0\u00bb Cardiovasc. Drugs Ther. Feb;21(1):47-53. 2007<\/p>\n 24.\u00a0Jayle C, Favreau F, Zhang KQ, Doucet C, Goujon JM, Hebrard W, Carretier M, Eugene M, Mauco G, Tillement JP, Hauet T. \u00ab\u00a0Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model.\u00a0\u00bb Am. J. physiol.-Renal physiol. 292(3): F1082-F1093. 2007<\/p>\n 25.\u00a0Doucet C, Zhang K, Desurmont T, Hebrard W, Scepi M, Nadeau C, Cau J, Leyre P, Febrer G, Carretier M, Richer JP, Papadopoulos V, Hauet T, Burucoa C, Goujon JM. \u00ab\u00a0Influence of warm ischemia time on peripheral-type benzodiazepine receptor: A new aspect of the role of mitochondria.\u00a0\u00bb Nephron Exp. Nephrol 107(1): E1-E11. 2007<\/p>\n 26.\u00a0Giraud S, Claire B, Eugene M, Debre P, Richard F, Barrou B. \u00ab\u00a0\u00a0\u00bbA new preservation solution increases islet yield and reduces graft immunogenicity in pancreatic islet transplantation.\u00a0\u00bb (vol 83, pg 1397, 2007).\u00a0\u00bb Transplantation 84(4): 561-561. 2007<\/p>\n 27.\u00a0Zhang KQ, Desurmont T, Goujon JM, Favreau F, Cau J, Deretz S, Mauco G, Carretier M, Papadopoulos V, Hauet T. \u00ab\u00a0Modulation of peripheral-type benzodiazepine receptor during ischemia reperfusion injury in a pig kidney model: A new partner of leukemia inhibitory factor in tubular regeneration.\u00a0\u00bb J. Am. Coll. Surg. 203(3): 353-364. 2006<\/p>\n 28.\u00a0Zhang KQ, Demeure O, Belliard A, Goujon JM, Favreau F, Desurmont T, Mauco G, Barriere M, Carretier M, Milan D, Papadopoulos V, Hauet T. \u00ab\u00a0Cloning, sequencing, and chromosomal localization of pig peripheral benzodiazepine receptor: three different forms produced by alternative splicing.\u00a0\u00bb Mamm. Genome 17(10): 1050-1062. 2006<\/p>\n 29.\u00a0Badet L, Eugene M,\u00a0 Hauet T, Barrou B. \u00ab\u00a0The use of preservation solutions in renal transplantation.\u00a0\u00bb Prog. Urol. 16:25-31. 2006<\/p>\n 30.\u00a0Neuzillet Y, Giraud S, Lagorce L, Eugene M, Richard F, Debre P, Barrou B. \u00ab\u00a0In vivo comparison of preservation of murine islets of Langerhans.\u00a0\u00bb Prog. Urol. 16(1): 73-77. 2006<\/p>\n 31.\u00a0Jayle C, Milinkevitch S, Favreau F, Doucet C, Richer JP, Deretz S, Mauco G, Rabb H, Hauet T. \u00ab\u00a0Protective role of selectin ligand inhibition in a large animal model of kidney ischemia-reperfusion injury.\u00a0\u00bb Kidney Int. 69(10): 1749-1755. 2006<\/p>\n 32.\u00a0Godet C, Goujon JM, Petit I, Lecron JC, Hauet T, Mauco G, Carretier M, Robert R. \u00ab\u00a0Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats.\u00a0\u00bb Shock 25(4): 384-388. 2006<\/p>\n 33.\u00a0Dutheil D, Rioja-Pastor I, Tallineau C, Goujon JM, Hauet T, Mauco G, Petit-Paris I. \u00ab\u00a0Protective effect of PEG 35000 Da on renal cells: Paradoxical activation of JNK signaling pathway during cold storage.\u00a0\u00bb Am. J. Transplant. 6(7): 1529-1540. 2006<\/p>\n 34.\u00a0Genesca M, Ivorra A, Sola A, Palacios L, Goujon JM, Hauet T, Villa R, Aguilo J, Hotter G. \u00ab\u00a0Electrical bioimpedance measurement during hypothermic rat kidney preservation for assessing ischemic injury.\u00a0\u00bb Biosens. Bioelectron. 20(9): 1866-1871. 2005<\/p>\n 35.\u00a0Hauet T, Yao ZX, Bose HS, Wall CT, Han Z, Li W, Hales DB, Miller WL, Culty M, Papadopoulos V. \u00ab\u00a0Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria.\u00a0\u00bb Mol. Endocrinol. Feb;19(2):540-54. 2005<\/p>\n 36.\u00a0Giraud S, Hauet T, Eugene M, Mauco G, Barrou B. \u00ab\u00a0A New Preservation Solution (SCOT 15) Improves the islet Isolation process from pancreata of Non-Heart-Beating Donors: A Murine Model.\u00a0\u00bb Transplant. Proc. 41(8): 3293-3295. 2009\u00a0\u00a0 8th Annual Congress of the French-Speaking-Society-of-Transplantation OCT, 2008 Quebec City, CANADA<\/p>\n 37.\u00a0Codas R, Badet L, Eugene M, Giraud S, Thuiller R, Hauet T. \u00ab\u00a0Evaluation of pulsatile Perfusion Machine RM3 for Kidney Preservation in a Swine Model of Renal Autotransplantation.\u00a0\u00bb Transplant. Proc. 41(8): 3296-3298. 2009\u00a0 8th Annual Congress of the French-Speaking-Society-of-Transplantation OCT, 2008 Quebec City, CANADA<\/p>\n 38.\u00a0Neuzillet Y, Giraud S, Lagorce L, Eugene M, Debre P, Richard F, Barrou B. \u00ab\u00a0Effects of the molecular weight of peg molecules (8, 20 and 35 KDA) on cell function and allograft survival prolongation in pancreatic islets transplantation.\u00a0\u00bb Transplant. Proc. 38(7): 2354-2355. 2006\u00a0\u00a0 5th Annual Conference of the French-Speaking-Society-of-Transplantation DEC 07-10, 2005 Tours, FRANCE<\/p>\n 39.\u00a0Brunet B, Doucet C, Venisse N, Hauet T, Hebrard W, Papet Y, Mauco G, Mura P. \u00ab\u00a0Validation of Large White Pig as an animal model for the study of cannabinoids metabolism: Application to the study of THC distribution in tissues.\u00a0\u00bb Forensic Sci.Int. 161(2-3): 169-174. 2006\u00a0\u00a0 43rd International Conference of the International-Association-of-Forensic-Toxicologists (TIAFT) AUG 29-SEP 02, 2005 Seoul, SOUTH KOREA<\/p>\n 40.\u00a0Rigoard P, Buffenoir K, Chaillou M, Fares M, Da Costa L, Boildieu N, Seguin F, Lapierre F, Maixent JM, Bauche S, Koenig J, Hanta\u00ef D. \u00ab\u00a0Morphological study of CNS lesions and the consequences on rat neuromuscular junction and peripheral nerve using confocal laser scanning microscopy and Koelle’s technique. \u00ab\u00a0Neurochirurgie. Mar;55 Suppl 1:S110-23. 2009<\/p>\n 41.\u00a0Rigoard P, Buffenoir K, Bauche S, Fares M, Koenig J, Hanta\u00ef D, Giot JP, Seguin F, Huze C, Schaeffer L, Maixent JM. \u00ab\u00a0Tools and techniques dedicated to neuromuscular junction observation.\u00a0\u00bb Neurochirurgie. Mar;55 Suppl 1:S43-8. 2009<\/p>\n 42.\u00a0Rigoard P, Bauche S, Buffenoir K, Da Costa L, Boildieu N, Seguin F, Koenig J, Lapierre F, Maixent JM. \u00ab\u00a0Pathophysiological, molecular and metabolic changes at the neuromuscular junction and the peripheral nerve after central nervous system lesions in humans.\u00a0\u00bb Neurochirurgie. Mar;55 Suppl 1:S135-47. 2009<\/p>\n 43.\u00a0Rigoard P, Buffenoir K, Fares M, Chaillou M, Da Costa L, Boildieu N, Seguin F, Huze C, Schaeffer L, Lapierre F, Maixent JM. \u00ab\u00a0Toward a metabolic approach of the central pattern generator concept in a spinal rat model.\u00a0\u00bb Neurochirurgie. Mar;55 Suppl 1:S124-34. 2009<\/p>\n 44.\u00a0Rigoard S, Wager M, Buffenoir K, Bauche S, Giot JP, Maixent JM, Rigoard P. Major mechanisms involved in the synaptic transmission of the neuromuscular apparatus. Neurochirurgie. Mar;55 Suppl 1:S22-33. Review. 2009<\/p>\n 45.\u00a0Rigoard P,\u00a0 Chaillou M, Fares M, Sottejeau Y, Giot JP, Honfo-Ga C, Rohan J, Lapierre F, Maixent JM. \u00ab\u00a0Energetic applications: Na+\/K+-ATPase and neuromuscular transmission.\u00a0\u00bb Neurochirurgie. Mar;55 Suppl 1:S92-103. Review. 2009.<\/p>\n\n\n
\n Last name, first name<\/td>\n Rank \/ Function (PU = university professor; PH = hospital practitioner<\/td>\n \n \n \n \n \n \n Yes<\/td>\n<\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n Engineer<\/td>\n \n \n \n \n \n \n \n \n \n \n \n <\/td>\n<\/tr>\n \n \n \n \n \n \n \n Technical assistant<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n
\n Last name, first name<\/td>\n Thesis supervisor<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n