{"id":74830755,"date":"2026-10-09T09:44:14","date_gmt":"2026-10-09T07:44:14","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=74830755"},"modified":"2026-10-09T09:45:22","modified_gmt":"2026-10-09T07:45:22","slug":"le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche\/","title":{"rendered":"Le projet PRELUDE, port\u00e9 par le Dr Clara Steichen, est laur\u00e9at de l&#8217;Agence nationale de la recherche"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Le projet s&#8217;appuie notamment sur des travaux d\u2019IRMETIST publi\u00e9s en 2024, qui ont montr\u00e9 que l&#8217;injection de v\u00e9sicules extracellulaires issues de cellules souches urinaires, combin\u00e9e \u00e0 une machine de perfusion d&#8217;organes, permettait d&#8217;am\u00e9liorer le conditionnement et la pr\u00e9servation du greffon r\u00e9nal \u00e0 court terme. Le principe est le suivant : lors d&#8217;une greffe de rein, l&#8217;organe pr\u00e9lev\u00e9 subit une p\u00e9riode sans circulation sanguine, suivie d&#8217;une reprise de celle-ci, qui provoque des l\u00e9sions susceptibles de d\u00e9grader le fonctionnement du greffon, c&#8217;est l&#8217;isch\u00e9mie reperfusion. Les v\u00e9sicules extracellulaires sont des petits \u00e9l\u00e9ments lib\u00e9r\u00e9s par les cellules souches, capables de participer \u00e0 la r\u00e9g\u00e9n\u00e9ration des tissus. La machine de perfusion permet quant \u00e0 elle de maintenir l&#8217;organe en dehors du corps dans des conditions plus proches de la physiologie, tout en administrant le traitement.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Le projet sera structur\u00e9 en trois \u00e9tapes :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>la premi\u00e8re consistera \u00e0 comparer, in vitro, diff\u00e9rents produits de th\u00e9rapie cellulaire afin de mettre au point un score capable d&#8217;\u00e9valuer leur potentiel r\u00e9g\u00e9n\u00e9ratif et de pr\u00e9dire leur efficacit\u00e9, limitant ainsi le recours aux mod\u00e8les animaux&nbsp;;<\/li>\n\n\n\n<li>la deuxi\u00e8me visera \u00e0 \u00e9lucider le m\u00e9canisme d&#8217;action de ces produits, gr\u00e2ce notamment \u00e0 des analyses de transcriptomique spatiale r\u00e9alis\u00e9es sur des reins de porc isol\u00e9s et perfus\u00e9s au laboratoire&nbsp;;<\/li>\n\n\n\n<li>la troisi\u00e8me consistera \u00e0 injecter le produit le plus performant dans un mod\u00e8le d&#8217;auto transplantation r\u00e9nale, avec un suivi \u00e0 trois mois du rein greff\u00e9, afin d&#8217;en \u00e9valuer l&#8217;efficacit\u00e9 \u00e0 long terme.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Le docteur Clara Steichen exerce au CHU de Poitiers en biochimie g\u00e9n\u00e9rale et sp\u00e9cialis\u00e9e en parall\u00e8le de son travail de recherche \u00e0 IRMETIST. Le projet PRELUDE est un projet d\u2019\u00e9quipe incluant diff\u00e9rents membres d\u2019IRMETIST (m\u00e9decins\/chercheurs, ing\u00e9nieurs et techniciens) ainsi que des collaborateurs europ\u00e9ens (Li\u00e8ge, Coimbra).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Un second financement ANR \u00ab&nbsp;Jeunes chercheuses et jeunes chercheurs&nbsp;\u00bb a \u00e9t\u00e9 obtenu \u00e0 IRMETIST, cette ann\u00e9e, par Nicolas M\u00e9lis, titulaire d\u2019une chaire de professeur junior. Ce projet nomme DIPPL porte sur l\u2019imagerie dynamique du foie sain et pathologique par microscopie multiphoton.<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"<p>Le projet PRELUDE (\u00ab Perfusion-based REgeneration of kidney grafts using Living stem cells or their DErivatives \u00bb), port\u00e9 par le Dr Clara Steichen\u2026","protected":false},"author":12,"featured_media":74830865,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[96],"tags":[],"class_list":["post-74830755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Le projet PRELUDE, port\u00e9 par le Dr Clara Steichen, est laur\u00e9at de l&#039;Agence nationale de la recherche - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le projet PRELUDE, port\u00e9 par le Dr Clara Steichen, est laur\u00e9at de l&#039;Agence nationale de la recherche - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Le projet PRELUDE (\u00ab Perfusion-based REgeneration of kidney grafts using Living stem cells or their DErivatives \u00bb), port\u00e9 par le Dr Clara Steichen au sein de l&#039;unit\u00e9 IRMETIST (Inserm U1313 \/ Universit\u00e9 de Poitiers), a \u00e9t\u00e9 retenu dans le cadre de l&#039;appel \u00e0 projets g\u00e9n\u00e9rique 2026 de l&#039;Agence nationale de la recherche (ANR), dans la cat\u00e9gorie \u00ab\u00a0Jeunes chercheuses et jeunes chercheurs\u00a0\u00bb. Ce financement national, d&#039;une dur\u00e9e de quatre ans, d\u00e9bute le 1er janvier 2027 et pr\u00e9voit notamment le recrutement d&#039;un doctorant.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.chu-poitiers.fr\/le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche\/\" \/>\n<meta property=\"og:site_name\" content=\"Site du CHU de Poitiers\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-09T07:44:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-09T07:45:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2026\/10\/steichen_clara_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Morgane Pr\u00e9maud\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Morgane Pr\u00e9maud\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche\\\/\"},\"author\":{\"name\":\"Morgane Pr\u00e9maud\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#\\\/schema\\\/person\\\/c3b1c950cff7a774b33177b5cdabb2cb\"},\"headline\":\"Le projet PRELUDE, port\u00e9 par le Dr Clara Steichen, est laur\u00e9at de l&#8217;Agence nationale de la recherche\",\"datePublished\":\"2026-10-09T07:44:14+00:00\",\"dateModified\":\"2026-10-09T07:45:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche\\\/\"},\"wordCount\":399,\"publisher\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/steichen_clara_2.jpg\",\"articleSection\":[\"Non classifi\u00e9(e)\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche\\\/\",\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/le-projet-prelude-porte-par-le-dr-clara-steichen-est-laureat-de-lagence-nationale-de-la-recherche\\\/\",\"name\":\"Le projet PRELUDE, port\u00e9 par le Dr Clara Steichen, est laur\u00e9at de l'Agence nationale de la recherche - 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