{"id":74548881,"date":"2026-05-07T10:11:26","date_gmt":"2026-05-07T08:11:26","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=74548881"},"modified":"2026-05-07T10:12:24","modified_gmt":"2026-05-07T08:12:24","slug":"pr-jean-pierre-frat-une-deuxieme-publication-dans-le-new-england-journal-of-medicine","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/pr-jean-pierre-frat-une-deuxieme-publication-dans-le-new-england-journal-of-medicine\/","title":{"rendered":"Pr Jean-Pierre Frat\u00a0: une deuxi\u00e8me publication dans le New England Journal of Medicine"},"content":{"rendered":"\n

Le c\u0153ur de l\u2019expertise du service de r\u00e9animation repose sur l\u2019oxyg\u00e9noth\u00e9rapie \u00e0 haut d\u00e9bit (OHD), une technique qui a transform\u00e9 la prise en charge des patients en d\u00e9tresse respiratoire. Ce dispositif d\u00e9livre un flux important d’oxyg\u00e8ne tout en am\u00e9liorant significativement le confort du patient. Les travaux de recherche clinique successifs des professeurs Jean-Pierre Frat, Arnaud Thille et R\u00e9mi Coudroy ont confirm\u00e9 l\u2019OHD comme le traitement de choix. Les r\u00e9sultats d\u00e9montrent que cette m\u00e9thode diminue de fa\u00e7on probante le recours \u00e0 l’intubation, \u00e9pargnant ainsi aux patients les contraintes d’une proc\u00e9dure invasive. Ce b\u00e9n\u00e9fice clinique s’accompagne d’une optimisation des ressources hospitali\u00e8res, avec une r\u00e9duction moyenne d’un jour de la dur\u00e9e des s\u00e9jours en r\u00e9animation et du temps pass\u00e9 sous ventilation assist\u00e9e. Au plan individuel, cette approche am\u00e9liore le confort respiratoire et, par cons\u00e9quent, le bien-\u00eatre du patient.<\/p>\n\n\n\n

D\u00e8s 2015, l\u2019\u00e9tude pionni\u00e8re FLORALI, coordonn\u00e9e par le Pr Jean-Pierre Frat, avait d\u00e9montr\u00e9 que ce dispositif permettait de r\u00e9duire la mortalit\u00e9 chez les patients les plus gravement atteints, tout en \u00e9tant plus confortable. Ces r\u00e9sultats, publi\u00e9s en 2015 dans le New England Journal of Medicine,<\/em> revue scientifique de renomm\u00e9e mondiale, ont eu un retentissement consid\u00e9rable dans le domaine de la r\u00e9animation intensive.<\/p>\n\n\n\n

Avec l\u2019\u00e9tude SOHO, le Pr Jean-Pierre Frat a poursuivi ses recherches en se concentrant sur les patients souffrant d\u2019insuffisance respiratoire aigu\u00eb hypox\u00e9mique, dont pr\u00e8s de 90 % des cas sont li\u00e9s \u00e0 une pneumonie. Avec une cohorte de 1 110 patients, il s\u2019agit de la recherche la plus vaste jamais men\u00e9e sur le sujet. L\u2019objectif \u00e9tait de comparer l\u2019efficacit\u00e9 de l\u2019oxyg\u00e9noth\u00e9rapie \u00e0 haut d\u00e9bit par rapport \u00e0 l\u2019oxyg\u00e9nation standard, afin de confirmer l’impact b\u00e9n\u00e9fique de cette technique sur la mortalit\u00e9.<\/p>\n\n\n\n

\u00ab Les progr\u00e8s constants de la m\u00e9decine, comme l’usage g\u00e9n\u00e9ralis\u00e9 des cortico\u00efdes et une ventilation m\u00e9canique plus protectrice, ne nous ont pas permis de d\u00e9montrer une baisse suppl\u00e9mentaire de la mortalit\u00e9. Les r\u00e9sultats de SOHO n’en demeurent pas moins cruciaux pour les patients et les h\u00f4pitaux <\/em>\u00bb, explique le Pr Frat. Les donn\u00e9es corroborent en effet les r\u00e9sultats des pr\u00e9c\u00e9dentes \u00e9tudes : r\u00e9duction du recours \u00e0 l’intubation, raccourcissement de la dur\u00e9e d\u2019hospitalisation, diminution du temps pass\u00e9 sous ventilation artificielle et nette am\u00e9lioration du sentiment d\u2019essoufflement.<\/p>\n\n\n\n

Les r\u00e9sultats de l\u2019\u00e9tude SOHO ont \u00e9t\u00e9 publi\u00e9s en mars 2026 dans le prestigieux New England Journal of Medicine<\/em> sous le titre \u00ab High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure \u00bb. C\u2019est la deuxi\u00e8me fois que les travaux du Pr Jean-Pierre Frat font l\u2019objet d\u2019une publication dans cette revue, une raret\u00e9 scientifique qui m\u00e9rite d’\u00eatre soulign\u00e9e. Cette cons\u00e9cration vient confirmer l\u2019expertise mondiale des chercheurs du service de m\u00e9decine intensive-r\u00e9animation du CHU de Poitiers. L\u2019\u00e9ditorial de la revue souligne d’ailleurs l\u2019implication majeure des \u00e9quipes poitevines dans ce domaine. \u00ab Poitiers est une ville moyenne, mais nous avons prouv\u00e9 que nous sommes capables de mener des \u00e9tudes massives et de les porter jusqu’aux plus grandes revues mondiales<\/em> \u00bb, conclut le Pr Frat.<\/p>\n\n\n\n

Lors de la crise li\u00e9e \u00e0 la pand\u00e9mie de covid-19 en 2020, l\u2019\u00e9tude SOHO a \u00e9t\u00e9 d\u00e9clin\u00e9e en \u00e9tude SOHO-COVID pour s\u2019adapter \u00e0 la situation sanitaire. Conduite dans trente centres fran\u00e7ais, l\u2019\u00e9tude a inclus 700 patients pour comparer l\u2019oxyg\u00e9noth\u00e9rapie \u00e0 haut d\u00e9bit (OHD) aux m\u00e9thodes classiques. Si la mortalit\u00e9 est rest\u00e9e comparable, l’OHD s’est distingu\u00e9e par sa capacit\u00e9 \u00e0 \u00e9viter de nombreuses intubations, le taux chutant de 53 % \u00e0 45 %. Ce succ\u00e8s a d\u00e9finitivement impos\u00e9 cette technique comme un recours th\u00e9rapeutique majeur en p\u00e9riode pand\u00e9mique.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Lire l\u2019article du Pr Jean-Pierre Frat High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure<\/a> <\/p>\n\n\n\n

 Lire l\u2019\u00e9ditorial de la revue New England Journal of Medicine<\/a><\/p>\n\n\n","protected":false},"excerpt":{"rendered":"

Sous l’impulsion des professeurs Jean-Pierre Frat, Arnaud Thille et R\u00e9mi Coudroy, le CHU de Poitiers est devenu une r\u00e9f\u00e9rence mondiale dans\u2026","protected":false},"author":12,"featured_media":54497,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[96],"tags":[],"class_list":["post-74548881","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"acf":[],"yoast_head":"\nPr Jean-Pierre Frat\u00a0: une deuxi\u00e8me publication dans le New England Journal of Medicine - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/pr-jean-pierre-frat-une-deuxieme-publication-dans-le-new-england-journal-of-medicine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pr Jean-Pierre Frat\u00a0: une deuxi\u00e8me publication dans le New England Journal of Medicine - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Sous l'impulsion des professeurs Jean-Pierre Frat, Arnaud Thille et R\u00e9mi Coudroy, le CHU de Poitiers est devenu une r\u00e9f\u00e9rence mondiale dans le domaine des d\u00e9tresses respiratoires aigu\u00ebs. 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Cette excellence se traduit par des publications r\u00e9guli\u00e8res dans les revues scientifiques prestigieuses. 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