{"id":535749,"date":"2022-11-29T15:40:22","date_gmt":"2022-11-29T14:40:22","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=535749"},"modified":"2022-12-13T09:22:36","modified_gmt":"2022-12-13T08:22:36","slug":"deux-recherches-du-chu-de-poitiers-mises-a-lhonneur-au-niveau-international","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/deux-recherches-du-chu-de-poitiers-mises-a-lhonneur-au-niveau-international\/","title":{"rendered":"Deux recherches du CHU de Poitiers mises \u00e0 l’honneur au niveau international"},"content":{"rendered":"\n

Le Pr Arnaud Thille, chef du service de m\u00e9decine intensive r\u00e9animation, et le Pr Jean-Pierre Frat, m\u00e9decin r\u00e9animateur, ont pr\u00e9sent\u00e9 les r\u00e9sultats de leurs \u00e9tudes respectives lors du congr\u00e8s europ\u00e9en. Ils ont eu l\u2019honneur d\u2019exposer leurs travaux, le premier en session de cl\u00f4ture, le second, en session d\u2019ouverture de la manifestation. L\u2019\u00e9tude du Pr Frat, intitul\u00e9e SOHO, comparait deux techniques d\u2019oxyg\u00e9nation disponibles en r\u00e9animation : l\u2019oxyg\u00e9nation conventionnelle et l\u2019oxyg\u00e9noth\u00e9rapie nasale \u00e0 haut d\u00e9bit. Il s\u2019agissait d\u2019\u00e9valuer l\u2019efficacit\u00e9 de chacune pour \u00e9viter l\u2019intubation, la morbidit\u00e9 et la mortalit\u00e9. A l\u2019origine, le protocole de l\u2019\u00e9tude pour lequel le Pr Frat a obtenu un programme hospitalier de recherche clinique, se portait sur les patients souffrant d\u2019insuffisance respiratoire aigu\u00eb en g\u00e9n\u00e9ral. Avec l\u2019arriv\u00e9e de la crise sanitaire en 2020, l\u2019\u00e9tude s\u2019est concentr\u00e9e sur les patients covid 19. Trente centres nationaux ont particip\u00e9 \u00e0 la recherche qui a inclus 700 patients en moins d\u2019un an. L\u2019\u00e9tude a permis de d\u00e9terminer que si le taux de mortalit\u00e9 est le m\u00eame avec les deux m\u00e9thodes d\u2019oxyg\u00e9nation, l\u2019oxyg\u00e9nation \u00e0 haut d\u00e9bit permet de r\u00e9duire l\u2019intubation de 45 \u00e0 53 %. Les r\u00e9sultats de l\u2019\u00e9tude SOHO ont \u00e9t\u00e9 publi\u00e9s en septembre 2022 dans la revue m\u00e9dicale internationale Journal of the American Medical Association (JAMA).<\/em> Le Pr Thille et St\u00e9phanie Ragot, m\u00e9thodologiste du centre d\u2019investigation clinique, ont collabor\u00e9 \u00e0 cette \u00e9tude. Le Pr Thille, quant \u00e0 lui, a pr\u00e9sent\u00e9 les r\u00e9sultats de son \u00e9tude intitul\u00e9e TIP-EX<\/em>. Celle-ci consistait \u00e0 comparer deux techniques de sevrage pour l\u2019extubation qui doit \u00eatre r\u00e9alis\u00e9e le plus pr\u00e9cocement possible. Il est, en effet, recommand\u00e9 de r\u00e9aliser une \u00e9preuve de sevrage chez tous les patients intub\u00e9s depuis plus de 48h pour \u00e9valuer les conditions physiologiques de la respiration spontan\u00e9e apr\u00e8s extubation. Il existe deux modalit\u00e9s principales de r\u00e9alisation d\u2019\u00e9preuves de ventilation spontan\u00e9e (VS) : soit la ventilation spontan\u00e9e avec l\u2019aide inspiratoire sur le ventilateur, soit la ventilation spontan\u00e9e sur pi\u00e8ce en T qui est plus difficile \u00e0 r\u00e9aliser et qui peut retarder l\u2019extubation. Les conclusions de l\u2019\u00e9tude montrent qu\u2019un plus grande nombre de patients r\u00e9ussissent le premier test, qu\u2019un plus grand nombre d\u2019entre eux est extub\u00e9 dans les 24 heures et qu\u2019il n\u2019y a pas de diff\u00e9rence sur le risque de r\u00e9intubation. Elles sont importantes car la ventilation spontan\u00e9e avec l\u2019aide inspiratoire sur le ventilateur est plus facile \u00e0 r\u00e9aliser par les infirmi\u00e8res et permet d\u2019extuber les patients plus rapidement sans augmenter le taux d\u2019\u00e9chec. Le Pr Thille a obtenu un PHRC pour cette \u00e9tude qui a commenc\u00e9 le 31 janvier 2020, juste avant la covid. Pr\u00e8s de 1 000 patients ont \u00e9t\u00e9 inclus, un quart d\u2019entre eux \u00e9tant positifs \u00e0 la covid. Les r\u00e9sultats de l\u2019\u00e9tude sont parus dans la revue internationale The New England Journal of Medecine (NEJM), <\/em>situ\u00e9e au premier rang des revues de m\u00e9decine. Les travaux de recherches de Jean-Pierre Frat avaient d\u00e9j\u00e0 fait l\u2019objet d\u2019une publication dans cette m\u00eame revue en 2015. Pour le Pr Thille, \u00ab\u00a0c\u2019est une v\u00e9ritable reconnaissance. D\u2019autant plus qu\u2019il est assez exceptionnel qu\u2019une \u00e9quipe de recherche publie deux fois dans ce type de revue<\/em> \u00bb. Ces \u00e9tudes montrent \u00e9galement que les centres de r\u00e9animation ont continu\u00e9 de faire de la recherche pendant la crise sanitaire malgr\u00e9 la surcharge de travail.<\/p>\n

Consulter l\u2019article du Pr Arnaud Thille<\/a><\/p>\n

Consulter l\u2019article du Pr Jean-Pierre Frat<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Deux recherches men\u00e9es par le service de m\u00e9decine intensive r\u00e9animation du CHU de Poitiers ont r\u00e9cemment \u00e9t\u00e9 mises \u00e0 l\u2019honneur lors du congr\u00e8s\u2026","protected":false},"author":12,"featured_media":535779,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[96],"tags":[],"class_list":["post-535749","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"acf":[],"yoast_head":"\nDeux recherches du CHU de Poitiers mises \u00e0 l'honneur au niveau international - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/deux-recherches-du-chu-de-poitiers-mises-a-lhonneur-au-niveau-international\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Deux recherches du CHU de Poitiers mises \u00e0 l'honneur au niveau international - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Deux recherches men\u00e9es par le service de m\u00e9decine intensive r\u00e9animation du CHU de Poitiers ont r\u00e9cemment \u00e9t\u00e9 mises \u00e0 l\u2019honneur lors du congr\u00e8s de la Soci\u00e9t\u00e9 europ\u00e9enne de m\u00e9decine de soins intensifs qui s\u2019est tenu du 22 au 26 octobre 2022 \u00e0 Paris. 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