{"id":34111,"date":"2022-02-11T10:03:41","date_gmt":"2022-02-11T09:03:41","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=34111"},"modified":"2022-02-11T10:03:47","modified_gmt":"2022-02-11T09:03:47","slug":"une-grande-expertise-en-microbiote","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/une-grande-expertise-en-microbiote\/","title":{"rendered":"Une grande expertise en microbiote"},"content":{"rendered":"\n<h3>Les recherches sur le microbiote<\/h3>\n<p>Comme le souligne le Pr Burucoa, chef du service de bact\u00e9riologie et hygi\u00e8ne, le terme microbiote employ\u00e9 depuis une quinzaine d\u2019ann\u00e9e, est \u00ab\u00a0<em>un mot nouveau pour d\u00e9signer quelque chose que l\u2019on connait depuis tr\u00e8s longtemps\u00a0: la flore bact\u00e9rienne<\/em>\u00a0\u00bb. Il s\u2019agit de l\u2019ensemble des bact\u00e9ries, champignons et autres micro-organismes que le corps humain contient en grand nombre. Et si l\u2019on entend plus souvent parler de microbiote intestinal, nous retrouvons \u00e9galement ces niches \u00e9cologiques dans les poumons, la peau ou encore le vagin. S\u2019il est fait r\u00e9f\u00e9rence \u00e0 la flore bact\u00e9rienne d\u00e8s le 17<sup>e<\/sup> si\u00e8cle, ce n\u2019est qu\u2019au 20<sup>e<\/sup> si\u00e8cle que des chercheurs se sont vraiment pench\u00e9s sur le sujet notamment Th\u00e9odor Escherich qui a d\u00e9couvert <em>l\u2019Escherichia<\/em>. C\u2019est \u00e9galement \u00e0 cette \u00e9poque que les bact\u00e9ries, pr\u00e9sent\u00e9es jusqu\u2019alors comme pathog\u00e8nes, ont \u00e9t\u00e9 identifi\u00e9es comme pouvant \u00eatre b\u00e9n\u00e9fique pour l\u2019homme. \u00ab\u00a0<em>C\u2019est une d\u00e9couverte incroyable qui ouvre bien des pistes. La bact\u00e9rie ne signifie pas pathologie mais au contraire la vie, plein de choses positives. C\u2019est pourquoi vouloir tuer nos bact\u00e9ries, n\u2019est pas la bonne solution<\/em>\u00a0\u00bb, signale le Pr Burucoa. L\u2019apparition et la d\u00e9mocratisation des s\u00e9quenceurs haut d\u00e9bit aux alentours de 2013 vont permettre une grande avanc\u00e9e dans la connaissance du microbiote. \u00ab\u00a0<em>C\u2019est vraiment parce que les prix des \u00e9quipements ont baiss\u00e9 que l\u2019on peut travailler sur le microbiote. Son exploration avec des techniques de culture n\u2019avait permis que de d\u00e9couvrir 20% des bact\u00e9ries. Mais le s\u00e9quen\u00e7age reste cher, \u00e0 plus de 100 euros l\u2019\u00e9chantillon analys\u00e9<\/em>\u00a0\u00bb, explique le Dr Maxime Pichon, biologiste m\u00e9dical. Les recherches sur le microbiote ont explos\u00e9 depuis 2013 et des d\u00e9couvertes tr\u00e8s int\u00e9ressantes ont pu se faire, pr\u00e9cise le Pr Burucoa\u00a0: \u00ab\u00a0<em>On s\u2019aper\u00e7oit que le microbiote est fondamental pour notre sant\u00e9, pour notre immunit\u00e9, et bien d\u2019autres aspects. Les d\u00e9s\u00e9quilibres du microbiote sont vraisemblablement responsables de certaines pathologies comme la scl\u00e9rose en plaques ou la maladie de Crohn<\/em>\u00a0\u00bb.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><a href=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2022\/01\/pichon-buruccoa.jpg\"><img decoding=\"async\" src=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2022\/01\/pichon-buruccoa.jpg\" alt=\"\" class=\"wp-image-33745\" width=\"519\" height=\"389\"\/><\/a><\/figure><\/div>\n\n\n<h3>Une grande expertise sur le microbiote<\/h3>\n<p>Conscient de l\u2019int\u00e9r\u00eat d\u2019un s\u00e9quenceur haut d\u00e9bit pour les recherches sur le microbiote, le Pr Burucoa a coordonn\u00e9 le projet d\u2019acquisition d\u2019un \u00e9quipement d\u2019une valeur de plus de 400\u00a0000 euros. Install\u00e9 en 2018, le s\u00e9quenceur est utilis\u00e9 en microbiologie mais \u00e9galement en g\u00e9n\u00e9tique et canc\u00e9rologie. Le CHU de Poitiers \u00e9tait l\u2019un des premiers \u00e9tablissements hospitaliers \u00e0 s\u2019\u00e9quiper de ce type de technologie. Le Pr Burucoa a, ensuite, permis le recrutement du Dr Maxime Pichon, sp\u00e9cialiste des microbiotes, pour mettre en place et faire fonctionner, pour la microbiologie, une plateforme de s\u00e9quen\u00e7age haut d\u00e9bit avec les \u00e9quipements technologiques et informatiques n\u00e9cessaires. Parmi les premiers \u00e0 faire du s\u00e9quen\u00e7age du microbiote dans la r\u00e9gion, le Pr Burucoa et le Dr Pichon ont acquis une grande expertise dans les recherches sur le microbiote. \u00ab <em>C\u2019est l\u2019objet de nos recherches aussi bien hospitali\u00e8res qu\u2019universitaires.\u00a0Notre travail consiste justement \u00e0 \u00e9tudier ces flores extr\u00eamement diverses notamment gr\u00e2ce au s\u00e9quen\u00e7age haut d\u00e9bit. Ces m\u00e9thodes nous permettent d\u2019avoir des informations sur les bact\u00e9ries qui nous composent sans avoir besoin forc\u00e9ment de passer par des techniques conventionnelles o\u00f9 l\u2019on met les bact\u00e9ries sur une g\u00e9lose pour les faire pousser. Avec ces \u00e9quipements on g\u00e9n\u00e8re une quantit\u00e9 pharamineuse de donn\u00e9es qu\u2019il faut ensuite trier afin de les analyser et leur donner du sens<\/em>\u00a0\u00bb, indique le Dr Pichon. Forts de ces exp\u00e9riences ils proposent leurs comp\u00e9tences en s\u00e9quen\u00e7age de microbiote aux chercheurs des autres sp\u00e9cialit\u00e9s pour mener des recherches ensemble notamment sur le microbiote intestinal avec la gastro-ent\u00e9rologie (<em>Helicobacter pylori<\/em>), le microbiote cutan\u00e9 avec les protocoles antiseptiques des urgences\u00a0; <a href=\"https:\/\/www.fonds-alienor.fr\/wpd-projects\/comprendre-resistance-bacteries\/\">le microbiote pulmonaire et les infections s\u00e9v\u00e8res et\/ou multir\u00e9sistantes de r\u00e9animation <\/a>ou le microbiote g\u00e9nital masculin avec le laboratoire de procr\u00e9ation m\u00e9dicalement assist\u00e9e.<\/p>","protected":false},"excerpt":{"rendered":"<p>En quelques ann\u00e9es, le CHU de Poitiers a acquis une grande expertise dans le s\u00e9quen\u00e7age du microbiote gr\u00e2ce aux travaux de recherches men\u00e9s par\u2026","protected":false},"author":12,"featured_media":34113,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[96],"tags":[],"class_list":["post-34111","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Une grande expertise en microbiote - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/une-grande-expertise-en-microbiote\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une grande expertise en microbiote - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"En quelques ann\u00e9es, le CHU de Poitiers a acquis une grande expertise dans le s\u00e9quen\u00e7age du microbiote gr\u00e2ce aux travaux de recherches men\u00e9s par le Pr Christophe Burucoa et le Dr Maxime Pichon, tous deux membres de l\u2019\u00e9quipe Inserm U1070, pharmacologie des anti-infectieux. 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