{"id":32641,"date":"2021-11-19T08:52:34","date_gmt":"2021-11-19T07:52:34","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=32641"},"modified":"2021-11-19T08:52:51","modified_gmt":"2021-11-19T07:52:51","slug":"recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse\/","title":{"rendered":"Recherches sur l’\u00e9nerg\u00e9tique c\u00e9r\u00e9brale publi\u00e9es dans une revue prestigieuse"},"content":{"rendered":"\n

L\u2019\u00e9tude men\u00e9e en collaboration avec l\u2019\u00e9quipe M\u00e9taPat du centre de r\u00e9sonance magn\u00e9tique des syst\u00e8mes biologiques, CNRS\/Universit\u00e9 de Bordeaux, dirig\u00e9e par le Dr Anne-Karine Bouzier-Sore, est d\u2019autant plus int\u00e9ressante qu\u2019elle propose une alternative \u00e0 un dogme en vigueur dans le domaine de l\u2019\u00e9nerg\u00e9tique c\u00e9r\u00e9brale depuis les ann\u00e9es 50. Il s\u2019agit de celui d\u00e9finissant le glucose comme le principal substrat pouvant fournir l\u2019\u00e9nergie n\u00e9cessaire au fonctionnement des neurones et \u00e0 l\u2019activit\u00e9 c\u00e9r\u00e9brale. En s\u2019appuyant sur des exp\u00e9riences conduites in vivo<\/em>, les chercheurs de cette \u00e9tude ont confirm\u00e9 que les astrocytes, des cellules c\u00e9r\u00e9brales, avaient la capacit\u00e9 non seulement de d\u00e9tecter l\u2019activit\u00e9 des neurones, mais de l\u2019associer \u00e0 la production de lactate \u00e0 partir du glucose extracellulaire. De ces observations provient le concept de la navette lactate, ou astrocyte-neuron lactate shuttle (ANLS en anglais) qui propose que le lactate produit par les astrocytes soit transf\u00e9r\u00e9 aux neurones pour contribuer au soutien de leur activit\u00e9. Une autre avanc\u00e9e, soutenant ce concept, fut de montrer que ce lactate, jusqu\u2019alors consid\u00e9r\u00e9 comme un d\u00e9chet m\u00e9tabolique, pouvait constituer un substrat \u00e9nerg\u00e9tique utilis\u00e9 efficacement par les neurones. Enfin, ce transfert de lactate de l\u2019astrocyte vers le neurone a \u00e9t\u00e9 montr\u00e9 comme non seulement essentiel pour permettre l\u2019activation d\u2019une r\u00e9gion c\u00e9r\u00e9brale pr\u00e9cise (d\u00e9tect\u00e9e \u00e0 l\u2019aide des techniques d\u2019imagerie fonctionnelle modernes) mais aussi pour l\u2019accomplissement d\u2019une t\u00e2che d\u2019apprentissage li\u00e9e \u00e0 cette activation. Le lactate a aussi un effet neuroprotecteur qui pourrait permettre de soigner et pr\u00e9venir \u00e9ventuellement des l\u00e9sions c\u00e9r\u00e9brales dans certaines pathologies. L\u2019article d\u00e9crivant cette \u00e9tude est publi\u00e9 dans la revue Proceedings of the National Academy of Sciences USA<\/em> sous le titre de <\/em>Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance.<\/em> Les travaux ont b\u00e9n\u00e9fici\u00e9 du soutien financier de l\u2019agence nationale de la recherche. Ils ont \u00e9galement fait l\u2019objet d\u2019un travail de communication aupr\u00e8s du grand public avec la cr\u00e9ation de planches de bandes-dessin\u00e9es, en collaboration avec l\u2019artiste Matyo. F\u00e9licitations aux chercheurs ainsi qu\u2019au Pr Luc Pellerin, futur directeur de l\u2019U1082.<\/p>\n

Lire le r\u00e9sum\u00e9 de la publication<\/a>
En savoir plus<\/a>
Consultez les planches de bandes-dessin\u00e9es r\u00e9alis\u00e9es par l\u2019artiste Matyo<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Les recherches men\u00e9es par l\u2019\u00e9quipe du Pr Luc Pellerin de l\u2019unit\u00e9 Inserm U1082 du CHU de Poitiers en collaboration avec une \u00e9quipe de recherche\u2026","protected":false},"author":12,"featured_media":32671,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[96],"tags":[],"class_list":["post-32641","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"acf":[],"yoast_head":"\nRecherches sur l'\u00e9nerg\u00e9tique c\u00e9r\u00e9brale publi\u00e9es dans une revue prestigieuse - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/en\/recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recherches sur l'\u00e9nerg\u00e9tique c\u00e9r\u00e9brale publi\u00e9es dans une revue prestigieuse - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Les recherches men\u00e9es par l\u2019\u00e9quipe du Pr Luc Pellerin de l\u2019unit\u00e9 Inserm U1082 du CHU de Poitiers en collaboration avec une \u00e9quipe de recherche de Bordeaux font l\u2019objet d\u2019une reconnaissance scientifique. Les r\u00e9sultats de leur \u00e9tude portant sur l\u2019\u00e9nerg\u00e9tique c\u00e9r\u00e9brale viennent, en effet, d\u2019\u00eatre publi\u00e9s dans la prestigieuse revue "Proceedings of the National Academy of Sciences USA".\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.chu-poitiers.fr\/en\/recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse\/\" \/>\n<meta property=\"og:site_name\" content=\"Site du CHU de Poitiers\" \/>\n<meta property=\"article:published_time\" content=\"2021-11-19T07:52:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-11-19T07:52:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2021\/11\/PELLERIN-MAIRE-COSTA-3-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1013\" \/>\n\t<meta property=\"og:image:height\" content=\"690\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Morgane Pr\u00e9maud\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Morgane Pr\u00e9maud\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse\\\/\"},\"author\":{\"name\":\"Morgane Pr\u00e9maud\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#\\\/schema\\\/person\\\/c3b1c950cff7a774b33177b5cdabb2cb\"},\"headline\":\"Recherches sur l’\u00e9nerg\u00e9tique c\u00e9r\u00e9brale publi\u00e9es dans une revue prestigieuse\",\"datePublished\":\"2021-11-19T07:52:34+00:00\",\"dateModified\":\"2021-11-19T07:52:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse\\\/\"},\"wordCount\":431,\"publisher\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2021\\\/11\\\/PELLERIN-MAIRE-COSTA-3-1.jpg\",\"articleSection\":[\"Non classifi\u00e9(e)\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse\\\/\",\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/recherches-sur-lenergetique-cerebrale-publiees-dans-une-revue-prestigieuse\\\/\",\"name\":\"Recherches sur l'\u00e9nerg\u00e9tique c\u00e9r\u00e9brale publi\u00e9es dans une revue prestigieuse - 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