{"id":21556,"date":"2020-04-23T11:06:02","date_gmt":"2020-04-23T09:06:02","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=21556"},"modified":"2020-04-23T11:06:03","modified_gmt":"2020-04-23T09:06:03","slug":"le-chu-de-poitiers-sengage-dans-la-recherche-contre-le-covid-19","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/le-chu-de-poitiers-sengage-dans-la-recherche-contre-le-covid-19\/","title":{"rendered":"Le CHU de Poitiers s\u2019engage dans la recherche contre le covid-19"},"content":{"rendered":"\n<h3>\u00c9tude de grande envergure<\/h3>\n<p>Face \u00e0 l\u2019urgence de la situation sanitaire, le CHU d\u2019Angers, en partenariat avec d\u2019autres h\u00f4pitaux<a href=\"#_ftn1\" name=\"_ftnref1\">[1]<\/a>, a initi\u00e9 une \u00e9tude de grande ampleur sur 1 300 patients. Les crit\u00e8res d\u2019inclusion des patients se basent sur des donn\u00e9es r\u00e9centes laissant \u00e0 penser que les traitements \u00e0 l\u2019hydroxychloroquine sont plus efficaces s\u2019ils sont administr\u00e9s t\u00f4t aux patients, avant que la maladie ne s\u2019aggrave. Ainsi seuls les patients pr\u00e9sentant une forme non s\u00e9v\u00e8re de covid mais dont on sait qu\u2019il y a un risque important d\u2019aggravation, y sont inclus. Ces patients doivent \u00eatre volontaires, majeurs, diagnostiqu\u00e9s covid depuis moins de 48 h et pr\u00e9senter au moins l\u2019un des deux facteurs d\u2019\u00e9volution compliqu\u00e9e \u2013\u00a0 avoir plus de 75 ans et\/ou \u00eatre oxyg\u00e9nod\u00e9pendant. Les effets secondaires seront \u00e9troitement surveill\u00e9s\u00a0; si un nombre trop \u00e9lev\u00e9s d\u2019\u00e9v\u00e8nements ind\u00e9sirables vient \u00e0 \u00eatre constat\u00e9, l\u2019\u00e9tude sera arr\u00eat\u00e9e.<\/p>\n<h3>\u00c9tude simple et efficace<\/h3>\n<p>L\u2019\u00e9tude consiste \u00e0 \u00e9tudier les effets de la mol\u00e9cule sur la pathologie. Parmi les 1 300 patients, la moiti\u00e9 se verra administrer de l\u2019hydroxychloroquine tandis que l\u2019autre moiti\u00e9 recevra le placebo du m\u00e9dicament qui pr\u00e9sente les m\u00eames caract\u00e9ristiques apparentes que celles de la mol\u00e9cule compar\u00e9e. Ni les patients, ni les m\u00e9decins ne sauront qui prend quoi. Ce type d\u2019\u00e9tude dite\u00a0\u00ab\u00a0\u00e0 deux bras\u00a0\u00bb ou \u00ab\u00a0\u00e0 l\u2019aveugle\u00a0\u00bb est courant en recherche clinique. <em>\u00ab \u00c7a n\u2019a rien d\u2019extraordinaire, c\u2019est le b.a.-ba pour une \u00e9tude scientifique<\/em>. <em>Quand vous testez l\u2019efficacit\u00e9 d\u2019un m\u00e9dicament, il faut toujours avoir ce qu\u2019on appelle un groupe t\u00e9moin, un groupe de patients qui n\u2019est pas trait\u00e9. Sinon, on ne peut rien conclure de l\u2019\u00e9tude, on ne peut pas dire si l\u2019\u00e9volution des malades est spontan\u00e9e ou s\u2019il y a un lien avec le traitement \u00bb<\/em> explique le professeur France Roblot, cheffe du <a href=\"https:\/\/www.chu-poitiers.fr\/specialites\/medecine-interne-maladies-infectieuses-tropicales-medecine-generale\/\">service des maladies infectieuses du CHU de Poitiers<\/a>. C\u2019est un comit\u00e9 de surveillance ind\u00e9pendant qui va r\u00e9aliser un suivi des donn\u00e9es de s\u00e9curit\u00e9 et d\u2019efficacit\u00e9. Cette \u00e9tude simple et efficace permettra d\u2019apporter \u00a0une r\u00e9ponse rapide et irr\u00e9futable sur les effets de l\u2019hydroxychloroquine dans le traitement du covid-19. Des r\u00e9sultats sont attendus d\u2019ici quelques semaines. Si l\u2019efficacit\u00e9 de l\u2019hydroxychloroquine sur les patients covid-19 venait \u00e0 \u00eatre rapidement d\u00e9montr\u00e9e, l\u2019\u00e9tude serait interrompue pour permettre \u00e0 tous les patients d\u2019en b\u00e9n\u00e9ficier.<\/p>\n<h3>Aidez la recherche<\/h3>\n<p>Face \u00e0 la situation tr\u00e8s critique qui touche le monde entier, les \u00e9tablissements hospitaliers participants \u00e0 l\u2019\u00e9tude <em>Hycovid <\/em>ont accept\u00e9 de commencer le projet sans engagement financier pr\u00e9alable de l\u2019Etat ou de partenaires industriels. Sur les 850\u00a0000 euros pr\u00e9vus pour l\u2019\u00e9tude, le CHU d\u2019Angers supportera 600\u00a0000 euros notamment pour les pr\u00e9l\u00e8vements et les analyses biologiques, la logistique et la r\u00e9mun\u00e9ration du personnel.<\/p>\n<h3>Pour en savoir plus<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.chu-angers.fr\/\"><strong>CHU d\u2019Angers<\/strong><\/a><strong><br \/><\/strong><\/li>\n<li><strong><a href=\"https:\/\/www.chu-angers.fr\/le-chu-angers\/a-la-une\/communiques-de-presse\/communiques-annee-2020\/hycovid-pour-mettre-fin-au-debat-sur-l-hydroxychloroquine-dans-le-covid-19-93249.kjsp?RH=1435661742247\">Communiqu\u00e9 de presse<\/a><br \/><\/strong><\/li>\n<li><strong><a href=\"https:\/\/www.lanouvellerepublique.fr\/niort\/le-chu-de-poitiers-et-l-hopital-de-niort-veulent-mettre-fin-au-debat-sur-l-hydroxychloroquine\">Interview<\/a> du <\/strong><strong>professeur<\/strong> <strong>France Roblot, cheffe du<\/strong> <strong>service des maladies infectieuses<\/strong> <strong>du CHU de Poitiers, sur l\u2019\u00e9tude (<em>Nouvelle R\u00e9publique<\/em> du 08-04-2020)<br \/><\/strong><\/li>\n<\/ul>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\">[1]<\/a> CHU : Amiens, AP-HP (4 sites), Brest, Caen, Dijon, Limoges, Nantes, Poitiers, Rennes, Saint-Etienne, Toulouse, Tours, CHR d\u2019Orl\u00e9ans. CH : Agen, Cherbourg, Cholet,, Colmar, Laval, Lorient, Le Mans, Melun Monaco, Niort, Pontoise, Quimper Saint-Brieuc, Rez\u00e9, Roche\/Yon, Saint-Nazaire, Tourcoing, Valenciennes, Vannes, Versailles.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Le CHU de Poitiers s\u2019est associ\u00e9 avec 36 autres \u00e9tablissements hospitaliers fran\u00e7ais \u00e0 l\u2019\u00e9tude lanc\u00e9e d\u00e9but avril par le CHU d\u2019Angers,\u2026","protected":false},"author":1,"featured_media":21557,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-21556","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Le CHU de Poitiers s\u2019engage dans la recherche contre le covid-19 - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/le-chu-de-poitiers-sengage-dans-la-recherche-contre-le-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le CHU de Poitiers s\u2019engage dans la recherche contre le covid-19 - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Le CHU de Poitiers s\u2019est associ\u00e9 avec 36 autres \u00e9tablissements hospitaliers fran\u00e7ais \u00e0 l\u2019\u00e9tude lanc\u00e9e d\u00e9but avril par le CHU d\u2019Angers, Hycovid. 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