{"id":20510152,"date":"2023-11-24T13:57:39","date_gmt":"2023-11-24T12:57:39","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=20510152"},"modified":"2023-11-24T13:57:41","modified_gmt":"2023-11-24T12:57:41","slug":"endurhypox-mesurer-limpact-du-manque-doxygene-sur-lendurance-respiratoire","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/endurhypox-mesurer-limpact-du-manque-doxygene-sur-lendurance-respiratoire\/","title":{"rendered":"EndurHypox\u00a0: mesurer l\u2019impact du manque d\u2019oxyg\u00e8ne sur l\u2019endurance respiratoire"},"content":{"rendered":"\n<p><em>\u00ab\u00a0Mon tout premier sujet d\u2019\u00e9tude \u00e9tait l\u2019impact du manque de sommeil sur l\u2019endurance respiratoire\u00a0\u00bb<\/em>, \u00e9voque le Dr Christophe Rault, m\u00e9decin d\u00e9l\u00e9gu\u00e9 du CIC et porteur de l\u2019\u00e9tude EndurHypox<em>, \u00ab\u00a0et cette nouvelle \u00e9tude se place dans la continuit\u00e9 de ce premier travail\u00a0visant \u00e0 mieux comprendre les d\u00e9terminants de l\u2019endurance respiratoire \u00bb<\/em>. En effet, les patients souffrant d\u2019apn\u00e9es du sommeil, en plus de souffrir d\u2019un mauvais sommeil, sont expos\u00e9s \u00e0 des hypoxies r\u00e9p\u00e9t\u00e9es et parfois s\u00e9v\u00e8res pendant qu\u2019ils dorment. On constate \u00e9galement que ces patients souffrent fr\u00e9quemment d\u2019une moindre endurance musculaire par rapport \u00e0 la population g\u00e9n\u00e9rale. Or, le lien de cause \u00e0 effet entre ces deux \u00e9l\u00e9ments n\u2019a pas encore \u00e9t\u00e9 d\u00e9montr\u00e9. C\u2019est pr\u00e9cis\u00e9ment ce qui devrait \u00eatre mis en exergue par cette nouvelle \u00e9tude physiologique. Une meilleure compr\u00e9hension de l\u2019impact du manque d\u2019oxyg\u00e8ne sur la capacit\u00e9 de notre cerveau \u00e0 entrainer nos muscles pourrait aussi modifier et am\u00e9liorer la prise en charge des patients atteints de pathologies respiratoires aigu\u00ebs ou chroniques.<\/p>\n<p>Le CIC dispose d\u2019un \u00e9quipement unique en France dans un CHU, une chambre hypoxique. Celle-ci permet de mimer des conditions d\u2019altitude en modulant le pourcentage d\u2019oxyg\u00e8ne dans la pi\u00e8ce. <em>\u00ab\u00a0En conditions r\u00e9elles, c\u2019est la variation de la pression qui modifie l\u2019apport en oxyg\u00e8ne. Avec la chambre hypoxique, nous faisons varier directement la proportion de l\u2019oxyg\u00e8ne dans l\u2019air inspir\u00e9, en fonction de l\u2019altitude simul\u00e9e\u00a0\u00bb<\/em>, explique le Dr Rault. L\u2019objet de l\u2019\u00e9tude est d\u2019exposer des volontaires sains \u00e0 une hypoxie, c\u2019est-\u00e0-dire \u00e0 un pourcentage d\u2019oxyg\u00e8ne plus faible, de fa\u00e7on intermittente pendant six heures d\u2019affil\u00e9e, afin de mesurer les cons\u00e9quences sur leurs capacit\u00e9s ventilatoires. <em>\u00ab\u00a0Nous soumettrons les volontaires \u00e0 deux s\u00e9ries de tests, l\u2019une en hypoxie intermittente, et l\u2019autre en normoxie. Les volontaires ne sauront pas s\u2019ils sont dans l\u2019une ou l\u2019autre des conditions\u00a0\u00bb,<\/em> explique le Dr Rault. Les r\u00e9sultats seront ensuite compar\u00e9s afin de pouvoir en tirer des conclusions sur l\u2019impact du manque d\u2019oxyg\u00e8ne sur l\u2019endurance ventilatoire.<\/p>\n<p>La soci\u00e9t\u00e9 Aliz\u00e9 Domicile, repr\u00e9sent\u00e9e par son pr\u00e9sident Wilfrid Jaulin dont l\u2019activit\u00e9, soutient financi\u00e8rement cette nouvelle \u00e9tude clinique EndurHypox. Son activit\u00e9 est l\u2019assistance respiratoire \u00e0 domicile. Le soutien d\u2019Aliz\u00e9 Domicile, mais \u00e9galement celui de la soci\u00e9t\u00e9 ADS, devraient permettre \u00e0 l\u2019\u00e9tude de d\u00e9buter au d\u00e9but de l\u2019ann\u00e9e 2024, avec l\u2019ambition d\u2019inclure au minimum 23 volontaires.<\/p>\n<p>Ces financements sont destin\u00e9s en grande partie au d\u00e9dommagement des volontaires, au mat\u00e9riel, et enfin au personnel mobilis\u00e9 sur l\u2019\u00e9tude. <em>\u00ab\u00a0Ces financements permettent \u00e9galement le recrutement d\u2019\u00e9tudiants en sant\u00e9 souhaitant r\u00e9aliser un master 2\u00a0\u00bb<\/em>, pr\u00e9cise le Dr Rault. En effet, le CIC accueille chaque ann\u00e9e des \u00e9tudiants en master et des doctorants afin qu\u2019ils puissent <a href=\"https:\/\/www.chu-poitiers.fr\/faire-une-these-duniversite-au-centre-dinvestigation-clinique-cic1402\/\">y mener leurs travaux de recherche<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Le centre d\u2019investigation clinique CIC 1402 du CHU de Poitiers pr\u00e9pare une nouvelle \u00e9tude clinique, baptis\u00e9e EndurHypox, dont l\u2019objectif est\u2026","protected":false},"author":12,"featured_media":20510458,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[96],"tags":[],"class_list":["post-20510152","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>EndurHypox\u00a0: mesurer l\u2019impact du manque d\u2019oxyg\u00e8ne sur l\u2019endurance respiratoire - 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