{"id":16919,"date":"2018-09-18T16:11:50","date_gmt":"2018-09-18T14:11:50","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=16919"},"modified":"2021-04-20T18:06:18","modified_gmt":"2021-04-20T16:06:18","slug":"questions-au-dr-vincent-javaugue-hematologue","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/questions-au-dr-vincent-javaugue-hematologue\/","title":{"rendered":"Questions au Dr&nbsp;Vincent Javaugue, n\u00e9phrologue"},"content":{"rendered":"<p><strong>Docteur Javaugue, pouvez-vous nous expliquer ce qu\u2019est une gammapathie monoclonale ?<\/strong><br \/>\nLes gammapathies monoclonales correspondent \u00e0 la pr\u00e9sence dans le sang ou les urines d\u2019une immunoglobuline (anticorps) monoclonale produite par un clone de cellules du syst\u00e8me immunitaire. Elles peuvent entra\u00eener des complications r\u00e9nales multiples, la plus fr\u00e9quente s\u2019appelant l\u2019amylose AL. Dans 70% des cas, l\u2019amylose AL affecte les reins. La premi\u00e8re cons\u00e9quence est une fuite de prot\u00e9ines dans les urines, en particulier d\u2019albumine, se traduisant par des \u0153d\u00e8mes et en l\u2019absence de traitement par une insuffisance r\u00e9nale progressive. L\u2019amylose est un groupe de maladies ayant toutes en commun le d\u00e9p\u00f4t de prot\u00e9ines insolubles dans diff\u00e9rents organes. Une trentaine de prot\u00e9ines peuvent \u00eatre \u00e0 l\u2019origine d\u2019une amylose.\u00a0 En dehors de l\u2019amylose AL, l\u2019atteinte r\u00e9nale est souvent pr\u00e9dominante dans les amyloses AA (caus\u00e9e par l\u2019inflammation chronique) et certaines amyloses h\u00e9r\u00e9ditaires.<\/p>\n<p><strong>Quel est le traitement d\u2019une amylose ? Est-il le m\u00eame dans tous les cas ?<\/strong><br \/>\nNon, pas n\u00e9cessairement mais le but commun du traitement est de faire diminuer au maximum le taux sanguin de la prot\u00e9ine responsable des d\u00e9p\u00f4ts. Dans l\u2019amylose AL, il repose sur la destruction des cellules qui produisent les cha\u00eenes l\u00e9g\u00e8res d\u2019immunoglobulines monoclonales. On utilise, le plus souvent, les chimioth\u00e9rapies efficaces dans le traitement du my\u00e9lome (cancer de la moelle osseuse). Dans l\u2019amylose AL, les cellules atteintes n\u2019ont pas tendance \u00e0 prolif\u00e9rer comme dans le my\u00e9lome et elle n\u2019est donc pas consid\u00e9r\u00e9e comme un cancer.\u00a0 Dans l\u2019amylose AA, le traitement consiste \u00e0 contr\u00f4ler la cause de l\u2019inflammation. Dans certaines amyloses h\u00e9r\u00e9ditaires, lorsque la prot\u00e9ine anormale est produite par le foie, une transplantation de foie peut \u00eatre parfois envisag\u00e9e pour tarir la source de production de l\u2019amylose.\u00a0\u00a0\u00a0<\/p>\n<p><strong>Quels sont vos perspectives de recherche ?<\/strong><br \/>\nActuellement, je travaille sur les complications r\u00e9nales associ\u00e9es li\u00e9es aux gammapathies monoclonales. C\u2019est un travail qui s\u2019inscrit dans une collaboration avec l\u2019unit\u00e9 Inserm-CNRS du Pr\u00a0Michel Cogn\u00e9, de Limoges, le service d\u2019h\u00e9matologie du Pr Arnaud Jaccard au CHU de Limoges, le CIC Inserm 1402 de Poitiers (axe &#8220;THOR&#8221;) et le service de n\u00e9phrologie du CHU de Poitiers.\u00a0 En parall\u00e8le, des collaborations nationales et internationales (Pr Nelson Leung \u00e0 la Mayo Clinic) sont en cours pour pr\u00e9ciser les indications et \u00e9valuer les r\u00e9sultats de la transplantation r\u00e9nale chez les patients suivis pour une amylose AL ou une autre maladie \u00e0 d\u00e9p\u00f4ts d\u2019immunoglobulines monoclonales arrivant au stade d\u2019insuffisance r\u00e9nale terminale.<\/p>\n<p><strong>Vous \u00eates aussi enseignant \u00e0 l\u2019universit\u00e9 ?<\/strong><br \/>\nOui, je participe \u00e0 l\u2019enseignement des premier et deuxi\u00e8me cycles des \u00e9tudes m\u00e9dicales, \u00e0 l\u2019enseignement r\u00e9gional du troisi\u00e8me cycle des \u00e9tudes m\u00e9dicales et \u00e0 l\u2019enseignement aux externes du service de n\u00e9phrologie et transplantation r\u00e9nale. Je viens par ailleurs d\u2019\u00eatre nomm\u00e9 ma\u00eetre de conf\u00e9rences des universit\u00e9s.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Originaire de Charente, le docteur Vincent Javaugue a r\u00e9alis\u00e9 l\u2019ensemble de ses \u00e9tudes \u00e0 Poitiers. En 2008, il d\u00e9bute son internat dans le service\u2026","protected":false},"author":1,"featured_media":16920,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[28,1],"tags":[],"class_list":["post-16919","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nephrologie","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Questions au Dr&nbsp;Vincent Javaugue, n\u00e9phrologue - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/en\/questions-au-dr-vincent-javaugue-hematologue\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Questions au Dr&nbsp;Vincent Javaugue, n\u00e9phrologue - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Originaire de Charente, le docteur Vincent Javaugue a r\u00e9alis\u00e9 l\u2019ensemble de ses \u00e9tudes \u00e0 Poitiers. En 2008, il d\u00e9bute son internat dans le service d\u2019h\u00e9matologie et de th\u00e9rapie cellulaire, et poursuivra sa formation dans le service de n\u00e9phrologie et transplantation r\u00e9nale jusqu\u2019en 2013. Entre 2014 et 2016, le docteur Vincent Javaugue occupe la fonction de chef de clinique. Le n\u00e9phrologue obtient le titre de praticien hospitalier en novembre 2016. En parall\u00e8le \u00e0 ses \u00e9tudes de m\u00e9decine, il a effectu\u00e9 une ann\u00e9e recherche en 2012 \u00e0 Bruxelles dans le laboratoire de physiologie r\u00e9nale du Pr\u00a0Olivier Devuyst \u00e0 l\u2019universit\u00e9 catholique de Louvain. A ce jour, le n\u00e9phrologue travaille sur les complications r\u00e9nales associ\u00e9es aux gammapathies monoclonales dans le service du Pr Frank Bridoux, labellis\u00e9 centre de r\u00e9f\u00e9rence amylose AL et autres maladies de d\u00e9p\u00f4ts d\u2019immunoglobulines monoclonales depuis 2006.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.chu-poitiers.fr\/en\/questions-au-dr-vincent-javaugue-hematologue\/\" \/>\n<meta property=\"og:site_name\" content=\"Site du CHU de Poitiers\" \/>\n<meta property=\"article:published_time\" content=\"2018-09-18T14:11:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-04-20T16:06:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2018\/09\/javaugue_vincent.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"533\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"ChuPoitiers\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ChuPoitiers\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/questions-au-dr-vincent-javaugue-hematologue\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/questions-au-dr-vincent-javaugue-hematologue\\\/\"},\"author\":{\"name\":\"ChuPoitiers\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#\\\/schema\\\/person\\\/08e92cc802383a84a4efc3b8a6a6658c\"},\"headline\":\"Questions au Dr&nbsp;Vincent Javaugue, n\u00e9phrologue\",\"datePublished\":\"2018-09-18T14:11:50+00:00\",\"dateModified\":\"2021-04-20T16:06:18+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/questions-au-dr-vincent-javaugue-hematologue\\\/\"},\"wordCount\":529,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/questions-au-dr-vincent-javaugue-hematologue\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2018\\\/09\\\/javaugue_vincent.jpg\",\"articleSection\":[\"N\u00e9phrologie\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/questions-au-dr-vincent-javaugue-hematologue\\\/\",\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/questions-au-dr-vincent-javaugue-hematologue\\\/\",\"name\":\"Questions au Dr&nbsp;Vincent Javaugue, n\u00e9phrologue - 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