{"id":16902,"date":"2018-09-12T17:23:38","date_gmt":"2018-09-12T15:23:38","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=16902"},"modified":"2021-04-20T18:06:18","modified_gmt":"2021-04-20T16:06:18","slug":"questions-au-dr-tackwa-khalifeh-pediatre","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/questions-au-dr-tackwa-khalifeh-pediatre\/","title":{"rendered":"Questions au Dr&nbsp;Tackwa Khalifeh, p\u00e9diatre"},"content":{"rendered":"<p><strong>Docteur Khalifeh, pouvez-vous nous expliquer ce qu\u2019est la dr\u00e9panocytose ?<\/strong><br \/>\nLa dr\u00e9panocytose est une maladie g\u00e9n\u00e9tique du sang. Les globules rouges sont fragilis\u00e9s, ils se cassent ce qui g\u00e9n\u00e8re des complications plus ou moins graves telles que l\u2019an\u00e9mie, l\u2019isch\u00e9mie, des micro-caillots sanguins qui peuvent faire survenir des micros-infarctus osseux ou des accidents vasculaires c\u00e9r\u00e9braux. A ce jour, elle est incurable mais des traitements existent pour stabiliser son \u00e9volution et limiter les crises. C\u2019est une maladie que l\u2019on peut d\u00e9tecter tr\u00e8s t\u00f4t chez le nourrisson, \u00e0 deux ou trois semaines de vie.<\/p>\n<p><strong>A quoi est due la dr\u00e9panocytose ?<\/strong><br \/>\nC\u2019est assez difficile \u00e0 expliquer. C\u2019est une maladie tr\u00e8s pr\u00e9sente en Afrique et aux Antilles car certaines populations ont d\u00e9velopp\u00e9 une r\u00e9sistance naturelle au paludisme gr\u00e2ce \u00e0 une mutation g\u00e9n\u00e9tique au niveau de leur h\u00e9moglobine : ils sont ce qu\u2019on appelle &#8220;porteurs sains de l\u2019h\u00e9moglobine S&#8221; que l\u2019on appelle h\u00e9t\u00e9rozygote AS. Les gens en bonne sant\u00e9 une h\u00e9moglobine normale A. Les malades dr\u00e9panocytaires ont une h\u00e9moglobine S. La maladie se forme quand les deux parents porteurs AS donnent chacun la copie mut\u00e9e S du g\u00e8ne \u00e0 leur enfant.<\/p>\n<p><strong>Quels sont les traitements \u00e0 cette maladie ?<\/strong><br \/>\nIl y en a plusieurs mais ils ne permettent pas aux patients de gu\u00e9rir, juste d\u2019\u00e9viter des complications potentiellement fatales. Pour tous les dr\u00e9panocytaires normaux, il faut veiller \u00e0 beaucoup boire, \u00e0 \u00e9viter les efforts physiques et la chaleur. Ils ont un antibiotique tous les jours pour \u00e9viter les infections et des vitamines. Dans le cas de dr\u00e9panocytose plus s\u00e9v\u00e8re, la transfusion sanguine, voire la greffe de moelle osseuse sont envisag\u00e9es. Tous les enfants ont un suivi m\u00e9dical tous les trois mois. En France, l\u2019esp\u00e9rance de vie des dr\u00e9panocytaires monte jusqu\u2019\u00e0 60 ans. En Afrique, une grande proportion d\u2019enfants malades ne peut pas esp\u00e9rer vivre au-del\u00e0 d\u2019une dizaine d\u2019ann\u00e9es.<\/p>\n<p><strong>Comment avez-vous \u00e9t\u00e9 amen\u00e9e \u00e0 traiter la dr\u00e9panocytose des enfants ?<\/strong><br \/>\nA la base, je suis p\u00e9diatre et me suis engag\u00e9e vers la dr\u00e9panocytose, non pas par choix mais parce que c\u2019\u00e9tait une sp\u00e9cialit\u00e9 vacante lors de mon arriv\u00e9e au CHU&#8230; Et je ne regrette absolument pas ! Je suis passionn\u00e9e par mon travail car j\u2019adore \u00eatre au contact des enfants : ils sont directs, matures, tr\u00e8s r\u00e9sistants \u00e0 la douleur et une capacit\u00e9 d\u2019adaptation vraiment surprenante. Je suis la plupart de mes petits patients dr\u00e9panocytaires depuis leur naissance, un lien se cr\u00e9\u00e9 automatiquement avec eux et leurs familles. Si j\u2019avais plus de temps, j\u2019aimerai contribuer \u00e0 la recherche clinique afin d\u2019am\u00e9liorer la qualit\u00e9 de vie des patients dr\u00e9panocytaires.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>N\u00e9e \u00e0 Bordeaux, le docteur Tackwa Khalifeh a r\u00e9alis\u00e9 l\u2019ensemble de son cursus secondaire et universitaire dans la capitale poitevine. En 2001,\u2026","protected":false},"author":1,"featured_media":16903,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[50],"tags":[],"class_list":["post-16902","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pediatrie"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Questions au Dr&nbsp;Tackwa Khalifeh, p\u00e9diatre - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/questions-au-dr-tackwa-khalifeh-pediatre\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Questions au Dr&nbsp;Tackwa Khalifeh, p\u00e9diatre - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"N\u00e9e \u00e0 Bordeaux, le docteur Tackwa Khalifeh a r\u00e9alis\u00e9 l\u2019ensemble de son cursus secondaire et universitaire dans la capitale poitevine. 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