{"id":14759887,"date":"2023-08-25T09:12:45","date_gmt":"2023-08-25T07:12:45","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=14759887"},"modified":"2023-08-29T14:39:30","modified_gmt":"2023-08-29T12:39:30","slug":"irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/","title":{"rendered":"IRMETIST : un futur prometteur pour la transplantation r\u00e9nale"},"content":{"rendered":"\n<h3><strong>La x\u00e9nostransplantation, c\u2019est quoi&nbsp;? Pour quoi&nbsp;?<\/strong><\/h3>\n<figure id=\"attachment_14760325\" aria-describedby=\"caption-attachment-14760325\" style=\"width: 224px\" class=\"wp-caption alignright\"><a href=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2023\/08\/Pr-Thierry-Hauet.jpg\"><img decoding=\"async\" class=\"wp-image-14760325 size-full\" src=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2023\/08\/Pr-Thierry-Hauet.jpg\" alt=\"Pr Thierry Hauet\" width=\"224\" height=\"320\"><\/a><figcaption id=\"caption-attachment-14760325\" class=\"wp-caption-text\">Pr Thierry Hauet<\/figcaption><\/figure>\n<p>La x\u00e9notransplantation consiste \u00e0 transplanter l\u2019organe d\u2019un donneur dont l\u2019esp\u00e8ce biologique est diff\u00e9rente de celle du receveur. Elle se r\u00e9v\u00e8le \u00eatre une solution prometteuse pour pallier \u00e0 la p\u00e9nurie mondiale d\u2019organes. Du fait de ses nombreuses similarit\u00e9s physiologiques et morphologiques avec l\u2019homme, le porc est consid\u00e9r\u00e9 comme l\u2019esp\u00e8ce donneuse de choix. N\u00e9anmoins, pendant longtemps, la x\u00e9notransplantation \u00e0 partir de porc a \u00e9t\u00e9 confront\u00e9e \u00e0 un taux \u00e9lev\u00e9 d\u2019\u00e9checs provoqu\u00e9 par la pr\u00e9sence de x\u00e9noantig\u00e8nes chez l\u2019animal. Lorsqu\u2019ils sont pr\u00e9sents dans l\u2019organisme humain, ces antig\u00e8nes ext\u00e9rieurs \u00e0 l&#8217;organisme, induisent une tr\u00e8s forte r\u00e9action immunitaire du receveur entrainant le rejet des greffons. De nouvelles biotechnologies permettant la modification du g\u00e9nome porcin ont compl\u00e8tement r\u00e9volutionn\u00e9 la x\u00e9notransplantation en supprimant, chez les porcs, les enzymes responsables de la formation de x\u00e9noantig\u00e8nes. C\u2019est ainsi que, fin 2021, les premi\u00e8res x\u00e9notransplantations de reins de porcs g\u00e9n\u00e9tiquement modifi\u00e9s ont \u00e9t\u00e9 r\u00e9alis\u00e9es, aux \u00c9tats-Unis, avec succ\u00e8s chez des receveurs humains. Toutefois, la r\u00e9ponse immunitaire des patients recevant ce type de greffe n\u2019avait pas encore \u00e9t\u00e9 caract\u00e9ris\u00e9e, ce qui est pourtant primordial pour augmenter les chances de succ\u00e8s de la x\u00e9nogreffe. Pour d\u00e9crypter ces ph\u00e9nom\u00e8nes complexes de rejet de x\u00e9nogreffe chez l\u2019humain, une \u00e9tude, con\u00e7ue sous la houlette du Pr Alexandre Loupy<a href=\"#_ftn1\" name=\"_ftnref1\">[1]<\/a>, a r\u00e9uni un groupe pluridisciplinaire d\u2019experts&nbsp;parmi lesquels l\u2019institut de transplantation multi-organes et de m\u00e9decine r\u00e9g\u00e9n\u00e9ratrice PITOR de Paris, le Paris Cardiovascular Research Center (PARCC), les services de transplantation des H\u00f4pitaux Necker, Saint Louis et de l\u2019HEGP, le Centre m\u00e9dical universitaire Langone Health de New York, la NYU Grossman School of Medicine, l\u2019Universit\u00e9 de Pensylvanie, l\u2019Universit\u00e9 de Padoue et l\u2019\u00e9quipe IRMETIST (INSERM\/Universit\u00e9 de Poitiers)<a href=\"#_ftn2\" name=\"_ftnref2\">[2]<\/a>. \u00ab&nbsp;<em>Notre \u00e9quipe a collabor\u00e9 en apportant son expertise consid\u00e9rable et internationalement reconnue en physiologie et comportement r\u00e9nal porcin au cours du processus de transplantation d\u2019organes. Nous avons particuli\u00e8rement explor\u00e9 l\u2019isch\u00e9mie reperfusion et ses interactions avec l\u2019immunit\u00e9 inn\u00e9e, un m\u00e9canisme de d\u00e9fense ancestrale pr\u00e9sent d\u00e8s la naissance chez tous les \u00eatres vivants qu\u2019ils soient animaux ou v\u00e9g\u00e9taux. Elle fait intervenir des cellules et des mol\u00e9cules qui vont agir tr\u00e8s rapidement au cours d&#8217;une r\u00e9action appel\u00e9e la r\u00e9action inflammatoire. Ces recherches placent la France, plus pr\u00e9cis\u00e9ment notre communaut\u00e9 hospitalo-universitaire poitevine et notre r\u00e9gion, \u00e0 l\u2019avant-garde de la x\u00e9notransplantation <\/em>\u00bb, indique le Pr Thierry Hauet, chef du service de biochimie, co- coordonnateur du site de Poitiers pour la FHU SUPPORT et co-coordonnateur du r\u00e9seau HR2S (CHU et Universit\u00e9 de Poitiers). Afin de mieux caract\u00e9riser la r\u00e9ponse immunitaire des patients contre ces organes porcins, les chercheurs de l\u2019\u00e9tude ont d\u00e9cid\u00e9 d\u2019utiliser une approche innovante, dite multimodale, bas\u00e9e sur des technologies de pointe adapt\u00e9es pour le diagnostic de pr\u00e9cision. Une \u00e9tude exhaustive des x\u00e9notransplants utilisant des biotechnologies d\u2019immunologie et de microscopie mol\u00e9culaire capables de caract\u00e9riser et localiser pr\u00e9cis\u00e9ment les cellules immunitaires dans les greffons a \u00e9t\u00e9 r\u00e9alis\u00e9e. Les r\u00e9sultats ont d\u00e9montr\u00e9 que les patients pr\u00e9sentaient des signes pr\u00e9coces d\u2019une forme particuli\u00e8re de rejet, dite \u00ab&nbsp;m\u00e9di\u00e9e par les anticorps&nbsp;\u00bb, quasi invisibles avec les technologies de microscopie&nbsp;standard. Les chercheurs ont \u00e9galement observ\u00e9 des cellules inflammatoires dans les x\u00e9notransplants. Lors d\u2019une transplantation humaine, s\u2019il n\u2019est pas trait\u00e9 \u00e0 temps, ce type de rejet m\u00e9di\u00e9 par des anticorps, \u00e9volue in\u00e9luctablement vers la perte du greffon \u00e0 moyen ou long terme. Les chercheurs estiment qu&#8217;ils peuvent donc anticiper la m\u00eame \u00e9volution lors d&#8217;une x\u00e9notransplantation. Loin d\u2019\u00eatre un frein pour le d\u00e9veloppement ult\u00e9rieur de cette discipline, ces nouvelles donn\u00e9es ont permis \u00e0 l&#8217;\u00e9quipe dirig\u00e9e par le Pr Alexandre Loupy, d\u2019identifier des cibles mol\u00e9culaires pour optimiser les mod\u00e8les de porcs g\u00e9n\u00e9tiquement modifi\u00e9s et les traitements immunosuppresseurs \u00e0 administrer aux patients pour limiter le risque de rejet. Des mod\u00e8les de porcs surexprimant des g\u00e8nes qui permettent de limiter l\u2019infiltration des greffons par les cellules de l\u2019immunit\u00e9 inn\u00e9e sont d\u00e9j\u00e0 disponibles et seront \u00e0 \u00e9tudier plus en d\u00e9tail. De plus, le rejet m\u00e9di\u00e9 par les anticorps \u00e9tant bien connu en transplantation humaine, les traitements d\u00e9j\u00e0 existant pourront quant \u00e0 eux \u00eatre test\u00e9s en x\u00e9notransplantation afin d\u2019augmenter les chances de succ\u00e8s des prochains essais cliniques. \u00ab&nbsp; <em>Cette \u00e9tude ouvre de grandes perspectives pour aboutir un jour \u00e0 transplanter des reins de porcs g\u00e9n\u00e9tiquement modifi\u00e9s chez des receveurs humains vivants, avec une survie des greffons acceptable \u00e0 long terme. Les d\u00e9couvertes de ce travail ont \u00e9t\u00e9 identifi\u00e9es comme majeures par le National Institutes of Health (NIH), qui con\u00e7oit actuellement les futurs essais cliniques <\/em>\u00bb, pr\u00e9cise le Pr Thierry Hauet. Les r\u00e9sultats de l\u2019\u00e9tude intitul\u00e9e <em>\u00ab&nbsp;Immune response after pig-to-human xenotransplantation : a multimodal phenotyping study&nbsp;\u00bb<\/em> ont \u00e9t\u00e9 publi\u00e9s dans la renomm\u00e9e revue internationale, <em>The Lancet.<\/em><\/p>\n<p><a href=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2023\/08\/23tl2895_Lancet.pdf\">Lire l&#8217;article en anglais<\/a>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\">[1]<\/a> Le Pr Alexandre Loupy est n\u00e9phrologue \u00e0 l\u2019h\u00f4pital Necker &#8211; Enfants malades AP-HP, directeur de l&#8217;unit\u00e9 970 Approches multidimensionnelles en transplantation d\u2019organe et directeur de l\u2019Institut de transplantation multi-organes et de m\u00e9decine r\u00e9g\u00e9n\u00e9ratrice PITOR \u00e0 Universit\u00e9 Paris-Cit\u00e9.<\/p>\n<p><a href=\"#_ftnref2\" name=\"_ftn2\">[2]<\/a> L\u2019unit\u00e9 mixte de recherche IRMETIST (INSERM\/Universit\u00e9 de&nbsp; Poitiers) appartient \u00e0 l\u2019Institut f\u00e9d\u00e9ratif de recherche bio-sant\u00e9 de l\u2019Universit\u00e9 de Poitiers, \u00e0 la F\u00e9d\u00e9ration hospitalo-universitaire SUPORT (SUrvival oPtimization in ORgan Transplantation) et au R\u00e9seau r\u00e9gional de recherche HR2S (Humain recompos\u00e9 et reconstruit en sant\u00e9)<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019unit\u00e9 mixte de recherche IRMETIST (INSERM\/Universit\u00e9 de Poitiers) a particip\u00e9, aux c\u00f4t\u00e9s de partenaires prestigieux, \u00e0 une \u00e9tude sur la x\u00e9notransplantation\u2026","protected":false},"author":12,"featured_media":14760202,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[96],"tags":[],"class_list":["post-14759887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IRMETIST : un futur prometteur pour la transplantation r\u00e9nale - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IRMETIST : un futur prometteur pour la transplantation r\u00e9nale - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"L\u2019unit\u00e9 mixte de recherche IRMETIST (INSERM\/Universit\u00e9 de Poitiers) a particip\u00e9, aux c\u00f4t\u00e9s de partenaires prestigieux, \u00e0 une \u00e9tude sur la x\u00e9notransplantation qui a permis d\u2019\u00e9lucider pour la premi\u00e8re fois les m\u00e9canismes en jeu dans la r\u00e9ponse immunitaire survenant apr\u00e8s la greffe de reins de porcs g\u00e9n\u00e9tiquement modifi\u00e9s chez l\u2019Homme et d&#039;identifier des solutions th\u00e9rapeutiques pour pr\u00e9venir le rejet de l\u2019organe greff\u00e9. Les r\u00e9sultats de cette \u00e9tude ont fait l\u2019objet d\u2019une publication dans la revue The Lancet.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/\" \/>\n<meta property=\"og:site_name\" content=\"Site du CHU de Poitiers\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-25T07:12:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-08-29T12:39:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2023\/08\/Cover_PTG_xenotransplantation-web.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"934\" \/>\n\t<meta property=\"og:image:height\" content=\"582\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Morgane Pr\u00e9maud\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Morgane Pr\u00e9maud\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/\"},\"author\":{\"name\":\"Morgane Pr\u00e9maud\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#\\\/schema\\\/person\\\/c3b1c950cff7a774b33177b5cdabb2cb\"},\"headline\":\"IRMETIST : un futur prometteur pour la transplantation r\u00e9nale\",\"datePublished\":\"2023-08-25T07:12:45+00:00\",\"dateModified\":\"2023-08-29T12:39:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/\"},\"wordCount\":1039,\"publisher\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/Cover_PTG_xenotransplantation-web.jpg\",\"articleSection\":[\"Non classifi\u00e9(e)\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/\",\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/\",\"name\":\"IRMETIST : un futur prometteur pour la transplantation r\u00e9nale - Site du CHU de Poitiers\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/Cover_PTG_xenotransplantation-web.jpg\",\"datePublished\":\"2023-08-25T07:12:45+00:00\",\"dateModified\":\"2023-08-29T12:39:30+00:00\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/Cover_PTG_xenotransplantation-web.jpg\",\"contentUrl\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/Cover_PTG_xenotransplantation-web.jpg\",\"width\":934,\"height\":582,\"caption\":\"x\u00e9notransplantation\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#website\",\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/\",\"name\":\"Site du CHU de Poitiers\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#organization\",\"name\":\"CHU de Poitiers\",\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/Logo-Horizontal-CHU-Poitiers_Couleurs.png\",\"contentUrl\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/Logo-Horizontal-CHU-Poitiers_Couleurs.png\",\"width\":2245,\"height\":1064,\"caption\":\"CHU de Poitiers\"},\"image\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#\\\/schema\\\/person\\\/c3b1c950cff7a774b33177b5cdabb2cb\",\"name\":\"Morgane Pr\u00e9maud\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb33f5c6cef4d8e56c34655064d7f4177ed5bad496b9758d31d51b50aa264147?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb33f5c6cef4d8e56c34655064d7f4177ed5bad496b9758d31d51b50aa264147?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb33f5c6cef4d8e56c34655064d7f4177ed5bad496b9758d31d51b50aa264147?s=96&d=mm&r=g\",\"caption\":\"Morgane Pr\u00e9maud\"},\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/en\\\/author\\\/morgane-premaudchu-poitiers-fr\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"IRMETIST : un futur prometteur pour la transplantation r\u00e9nale - Site du CHU de Poitiers","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/","og_locale":"en_US","og_type":"article","og_title":"IRMETIST : un futur prometteur pour la transplantation r\u00e9nale - Site du CHU de Poitiers","og_description":"L\u2019unit\u00e9 mixte de recherche IRMETIST (INSERM\/Universit\u00e9 de Poitiers) a particip\u00e9, aux c\u00f4t\u00e9s de partenaires prestigieux, \u00e0 une \u00e9tude sur la x\u00e9notransplantation qui a permis d\u2019\u00e9lucider pour la premi\u00e8re fois les m\u00e9canismes en jeu dans la r\u00e9ponse immunitaire survenant apr\u00e8s la greffe de reins de porcs g\u00e9n\u00e9tiquement modifi\u00e9s chez l\u2019Homme et d'identifier des solutions th\u00e9rapeutiques pour pr\u00e9venir le rejet de l\u2019organe greff\u00e9. Les r\u00e9sultats de cette \u00e9tude ont fait l\u2019objet d\u2019une publication dans la revue The Lancet.","og_url":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/","og_site_name":"Site du CHU de Poitiers","article_published_time":"2023-08-25T07:12:45+00:00","article_modified_time":"2023-08-29T12:39:30+00:00","og_image":[{"width":934,"height":582,"url":"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2023\/08\/Cover_PTG_xenotransplantation-web.jpg","type":"image\/jpeg"}],"author":"Morgane Pr\u00e9maud","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Morgane Pr\u00e9maud","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/#article","isPartOf":{"@id":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/"},"author":{"name":"Morgane Pr\u00e9maud","@id":"https:\/\/www.chu-poitiers.fr\/#\/schema\/person\/c3b1c950cff7a774b33177b5cdabb2cb"},"headline":"IRMETIST : un futur prometteur pour la transplantation r\u00e9nale","datePublished":"2023-08-25T07:12:45+00:00","dateModified":"2023-08-29T12:39:30+00:00","mainEntityOfPage":{"@id":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/"},"wordCount":1039,"publisher":{"@id":"https:\/\/www.chu-poitiers.fr\/#organization"},"image":{"@id":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/#primaryimage"},"thumbnailUrl":"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2023\/08\/Cover_PTG_xenotransplantation-web.jpg","articleSection":["Non classifi\u00e9(e)"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/","url":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/","name":"IRMETIST : un futur prometteur pour la transplantation r\u00e9nale - Site du CHU de Poitiers","isPartOf":{"@id":"https:\/\/www.chu-poitiers.fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/#primaryimage"},"image":{"@id":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/#primaryimage"},"thumbnailUrl":"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2023\/08\/Cover_PTG_xenotransplantation-web.jpg","datePublished":"2023-08-25T07:12:45+00:00","dateModified":"2023-08-29T12:39:30+00:00","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.chu-poitiers.fr\/irmetist-une-etude-sur-la-xenotransplantation-publiee-dans-the-lancet\/#primaryimage","url":"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2023\/08\/Cover_PTG_xenotransplantation-web.jpg","contentUrl":"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2023\/08\/Cover_PTG_xenotransplantation-web.jpg","width":934,"height":582,"caption":"x\u00e9notransplantation"},{"@type":"WebSite","@id":"https:\/\/www.chu-poitiers.fr\/#website","url":"https:\/\/www.chu-poitiers.fr\/","name":"Site du CHU de Poitiers","description":"","publisher":{"@id":"https:\/\/www.chu-poitiers.fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.chu-poitiers.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.chu-poitiers.fr\/#organization","name":"CHU de Poitiers","url":"https:\/\/www.chu-poitiers.fr\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.chu-poitiers.fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2022\/02\/Logo-Horizontal-CHU-Poitiers_Couleurs.png","contentUrl":"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2022\/02\/Logo-Horizontal-CHU-Poitiers_Couleurs.png","width":2245,"height":1064,"caption":"CHU de Poitiers"},"image":{"@id":"https:\/\/www.chu-poitiers.fr\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.chu-poitiers.fr\/#\/schema\/person\/c3b1c950cff7a774b33177b5cdabb2cb","name":"Morgane Pr\u00e9maud","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/fb33f5c6cef4d8e56c34655064d7f4177ed5bad496b9758d31d51b50aa264147?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/fb33f5c6cef4d8e56c34655064d7f4177ed5bad496b9758d31d51b50aa264147?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fb33f5c6cef4d8e56c34655064d7f4177ed5bad496b9758d31d51b50aa264147?s=96&d=mm&r=g","caption":"Morgane Pr\u00e9maud"},"url":"https:\/\/www.chu-poitiers.fr\/en\/author\/morgane-premaudchu-poitiers-fr\/"}]}},"_links":{"self":[{"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/posts\/14759887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/comments?post=14759887"}],"version-history":[{"count":6,"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/posts\/14759887\/revisions"}],"predecessor-version":[{"id":15171967,"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/posts\/14759887\/revisions\/15171967"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/media\/14760202"}],"wp:attachment":[{"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/media?parent=14759887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/categories?post=14759887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.chu-poitiers.fr\/en\/wp-json\/wp\/v2\/tags?post=14759887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}