{"id":13943,"date":"2017-02-17T10:57:35","date_gmt":"2017-02-17T09:57:35","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=13943"},"modified":"2021-04-20T18:05:54","modified_gmt":"2021-04-20T16:05:54","slug":"tumorotheque-du-chu-objectif-certification","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/tumorotheque-du-chu-objectif-certification\/","title":{"rendered":"Tumoroth\u00e8que du CHU : objectif certification"},"content":{"rendered":"

“C’est tr\u00e8s important d’\u00eatre certifi\u00e9, car les chercheurs ne travaillent qu’avec des tumoroth\u00e8ques certifi\u00e9es”, indique le Dr Eric Frouin, anatomo-cyto-pathologiste au CHU de Poitiers. “Cela garantit que la collecte, la pr\u00e9paration, la conservation et la mise \u00e0 dispositions des \u00e9chantillons ont \u00e9t\u00e9 r\u00e9alis\u00e9es dans des conditions de qualit\u00e9 rigoureuses”, compl\u00e8te Mich\u00e8le Grosdenier, responsable fonctionnelle adjointe du CRB. C’est un gage de qualit\u00e9, exig\u00e9 depuis quelques ann\u00e9es par les chercheurs et dont la mention appara\u00eet de plus en plus dans les publications scientifiques. \u00a0Nous devons rattraper notre retard vis-\u00e0-vis des autres tumoroth\u00e8ques d\u00e9j\u00e0 certifi\u00e9es dans la grande r\u00e9gion Aquitaine.<\/p>\n

Graphique 1<\/figcaption><\/figure>\n

“Nous souhaitons sensibiliser les soignants, particuli\u00e8rement les m\u00e9decins, sur le caract\u00e8re indispensable du consentement des patients pour l’utilisation de leurs \u00e9chantillons. Des efforts importants ont \u00e9t\u00e9 entrepris depuis six mois, mais ils sont insuffisants, rappelle le Dr Frouin (voir graphique 1). Nous souhaitons aussi interpeller les m\u00e9decins du CHU et les chercheurs de notre r\u00e9gion sur les ressources biologiques conserv\u00e9es dans la tumoroth\u00e8que qui peuvent d\u00e8s \u00e0 pr\u00e9sent servir dans des protocoles de recherche r\u00e9gionaux ou nationaux.”<\/p>\n

Graphique 2<\/figcaption><\/figure>\n

En pratique, les pr\u00e9l\u00e8vements sont effectu\u00e9s dans les services ou au bloc op\u00e9ratoire une fois que le patient a re\u00e7u une information et sign\u00e9 un consentement \u00e9clair\u00e9. Il s\u2019agit de demandes de tissus, notamment de tumeurs. Une feuille de route \u00e9tablie par le CRB va les accompagner du lieu de leur pr\u00e9l\u00e8vement \u00e0 la tumoroth\u00e8que pour assurer la qualit\u00e9 du pr\u00e9l\u00e8vement. “Chaque pr\u00e9cieuse minute \u00e9coul\u00e9e entre le pr\u00e9l\u00e8vement et la cong\u00e9lation provoque une destruction des ADN, des ARN et des prot\u00e9ines. Ces pr\u00e9l\u00e8vements ne pourront donc pas \u00a0\u00eatre utilis\u00e9s pour la recherche”, explique le Dr Frouin. “Nos audits de qualit\u00e9 ont montr\u00e9 que le d\u00e9lai de cong\u00e9lation des pr\u00e9l\u00e8vements \u00e9tait trop long pour un tiers d\u2019entre eux”, ajoute Mich\u00e8le Grosdenier (voir le graphique\u00a02).<\/p>\n

L\u2019int\u00e9gration au CRB de la tumoroth\u00e8que permet aux deux entit\u00e9s – tumoroth\u00e8que et bioth\u00e8que – de s’interconnecter. L’objectif, outre la mutualisation du personnel, est de simplifier les proc\u00e9dures pour les chercheurs qui souhaitent acc\u00e9der aux pr\u00e9l\u00e8vements. “La certification nous a oblig\u00e9 \u00e0 harmoniser nos proc\u00e9dures. Il n’y a d\u00e9sormais plus qu’une seule proc\u00e9dure et un seul interlocuteur pour acc\u00e9der aux deux banques, simplifiant les d\u00e9marches pour les chercheurs”, explique Mich\u00e8le Grosdenier.<\/p>\n\n\n\n
Activit\u00e9 2016 de la tumoroth\u00e8que <\/strong><\/p>\n

Nombre d\u2019\u00e9chantillons re\u00e7us\u00a0: 1213<\/p>\n

Nombre d\u2019\u00e9chantillons sortis\u00a0 (incluant les blocs de paraffine) : 432<\/p>\n

Nombre total d\u2019\u00e9chantillons conserv\u00e9s au 31\/12\/2016\u00a0: 17\u00a0602<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"Tumoroth\u00e8que<\/p>\n

Fond\u00e9e en 2004 par le Pr Pierre Levillain, la tumoroth\u00e8que est devenue en 2009 un \u00e9tablissement r\u00e9gional et conserve des pr\u00e9l\u00e8vements provenant de malades d\u2019h\u00f4pitaux publics et d\u2019\u00e9tablissements priv\u00e9s de l’ex r\u00e9gion Poitou-Charentes. Elle relevait du service d\u2019anatomie pathologique et a \u00e9t\u00e9 g\u00e9r\u00e9e par Martine Potiron, cadre de sant\u00e9, avec l\u2019aide technique de C\u00e9line Archaimbault, technicienne en anatomie et cytologie pathologique, jusqu\u2019en avril 2016 avant son int\u00e9gration au CRB. C\u2019est d\u00e9sormais Liliane Berland qui assure la partie technique avec le Dr Frouin et Mich\u00e8le Grosdenier.<\/p>\n\n\n\n
Comment solliciter la tumoroth\u00e8que<\/strong><\/p>\n

Pour toutes les demandes de mises en place d\u2019une nouvelle collection ou d\u2019acc\u00e8s \u00e0 des \u00e9chantillons (mise \u00e0 disposition)\u00a0:<\/p>\n

    \n
  1. Le demandeur transmet une demande au CRB<\/li>\n
  2. Le comit\u00e9 scientifique du CRB \u00e9tudie la faisabilit\u00e9 et estime le co\u00fbt de la demande.<\/li>\n
  3. Un devis est \u00e9tabli par le CRB.<\/li>\n
  4. Pour une nouvelle collection, une convention est \u00e9tablie entre le responsable de l\u2019\u00e9tude et la direction de la recherche.<\/li>\n
  5. Pour une mise \u00e0 disposition, le CRB effectue celle-ci et une facture est \u00e9tablie apr\u00e8s r\u00e9ception des \u00e9chantillons.<\/li>\n<\/ol>\n

    Pour chaque \u00e9tape, le demandeur b\u00e9n\u00e9ficiera de l\u2019appui et de l\u2019aide technique du CRB.<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Au CHU de Poitiers, c’est le centre de ressources biologiques (CRB) qui r\u00e9ceptionne, conserve et met \u00e0 disposition les ressources biologiques\u2026","protected":false},"author":1,"featured_media":13971,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[48],"tags":[],"class_list":["post-13943","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anatomie-et-cytologie-pathologiques"],"acf":[],"yoast_head":"\nTumoroth\u00e8que du CHU : objectif certification - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/tumorotheque-du-chu-objectif-certification\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tumoroth\u00e8que du CHU : objectif certification - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Au CHU de Poitiers, c'est le centre de ressources biologiques (CRB) qui r\u00e9ceptionne, conserve et met \u00e0 disposition les ressources biologiques solides (tumoroth\u00e8que) et liquides (bioth\u00e8que) \u00e0 des fins de recherche. 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