{"id":13163,"date":"2016-10-17T16:34:14","date_gmt":"2016-10-17T14:34:14","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=13163"},"modified":"2021-04-20T18:05:47","modified_gmt":"2021-04-20T16:05:47","slug":"questions-a-rapahel-thuillier-chercheur-en-biochimie","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/questions-a-rapahel-thuillier-chercheur-en-biochimie\/","title":{"rendered":"Questions \u00e0 Rapha\u00ebl Thuillier, chercheur en biochimie"},"content":{"rendered":"

Quels sont les axes de recherche de l\u2019\u00e9quipe Inserm U1082 ?
\n<\/strong>Nous travaillons sur l\u2019am\u00e9lioration des conditions de la transplantation d\u2019organes, en \u00e9tudiant plus particuli\u00e8rement les syndromes li\u00e9s \u00e0 l\u2019isch\u00e9mie-reperfusion. Il s\u2019agit du stress subi par l\u2019organe entre le moment de l\u2019isch\u00e9mie, lorsqu\u2019il est pr\u00e9lev\u00e9 sur le donneur et coup\u00e9 du circuit sanguin, et celui o\u00f9 il est r\u00e9implant\u00e9, lorsque l\u2019on proc\u00e8de \u00e0 la reperfusion sanguine. L\u2019organe est conserv\u00e9 hors du corps dans de la glace, parfois pendant plus de 24h pour le rein. Diff\u00e9rents processus se mettent en place et influencent de fa\u00e7on majeure la qualit\u00e9 du greffon, et donc le comportement de l\u2019organe \u00e0 la reperfusion. En lien avec le service de r\u00e9animation, nous \u00e9tudions \u00e9galement ce qui se passe avant l\u2019isch\u00e9mie au niveau du donneur.<\/p>\n

Quels sont les enjeux de vos travaux sur l\u2019isch\u00e9mie-reperfusion ?
\n<\/strong>L\u2019int\u00e9r\u00eat est de mieux conna\u00eetre les ph\u00e9nom\u00e8nes l\u00e9sionnels de fa\u00e7on \u00e0 mesurer leur activation et quantifier la qualit\u00e9 de l\u2019organe, pour apporter un traitement personnalis\u00e9 au receveur. A plus long terme, l\u2019objectif est de mettre en place des moyens de traiter l\u2019organe, avant la greffe, pour augmenter sa qualit\u00e9. Id\u00e9alement, nous pourrons \u00e0 l\u2019avenir utiliser des organes actuellement refus\u00e9s en raison d\u2019une qualit\u00e9 jug\u00e9e insuffisante. Il faut savoir que 10 \u00e0 20% des organes pr\u00e9lev\u00e9s et transport\u00e9s ne sont pas s\u00e9lectionn\u00e9s, alors que les besoins sont grands \u00e0 travers le monde : en moyenne, un quart seulement des demandes de patients sur liste d\u2019attente sont aujourd\u2019hui satisfaites.<\/p>\n

Comment mettez-vous \u00e0 profit votre sp\u00e9cialit\u00e9 en recherche translationnelle ?
\n<\/strong>La recherche translationnelle vise \u00e0 trouver comment appliquer ce que l\u2019on a d\u00e9couvert en laboratoire \u00e0 des technologies th\u00e9rapeutiques ou diagnostiques chez le patient. C\u2019est dans cette optique que j\u2019int\u00e8gre le laboratoire de biochimie : \u00e0 partir des connaissances d\u00e9velopp\u00e9es au laboratoire de l\u2019Inserm, nous allons chercher \u00e0 mettre en place des outils de diagnostic de la qualit\u00e9 des greffons \u00e0 l\u2019h\u00f4pital.<\/p>\n

Votre unit\u00e9 est-elle la seule \u00e0 \u00e9tudier ces probl\u00e9matiques ? Comment les recherches sont-elle organis\u00e9es ?
\n<\/strong>D\u2019autres centres de recherche en France travaillent aussi sur la transplantation d\u2019organe et l\u2019isch\u00e9mie-reperfusion. Nous nous inscrivons dans diff\u00e9rents r\u00e9seaux nationaux, europ\u00e9ens et internationaux. Au niveau local, en 2014, nous avons int\u00e9gr\u00e9 la dynamique de la f\u00e9d\u00e9ration hospitalo-universitaire SUPORT (SUrvival oPtimization in ORgan Transplantation), relative aux greffes et conservation d\u2019organes, coordonn\u00e9e par le Pr Thierry Hauet, associant des \u00e9quipes des CHU de Poitiers, Limoges et Tours.<\/p>\n

* L\u2019unit\u00e9 U1082 a succ\u00e9d\u00e9 en 2012 \u00e0 l\u2019unit\u00e9 U927, dirig\u00e9e par le Pr G\u00e9rard Mauco.<\/p>\n","protected":false},"excerpt":{"rendered":"

Rapha\u00ebl Thuillier est ing\u00e9nieur de recherche pour le service de biochimie, d\u00e9tach\u00e9 au sein l\u2019unit\u00e9 Inserm U1082 du Pr Thierry Hauet depuis 2008*.\u2026","protected":false},"author":1,"featured_media":13164,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[47,41],"tags":[],"class_list":["post-13163","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biologie-medicale","category-recherche"],"acf":[],"yoast_head":"\nQuestions \u00e0 Rapha\u00ebl Thuillier, chercheur en biochimie - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/questions-a-rapahel-thuillier-chercheur-en-biochimie\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Questions \u00e0 Rapha\u00ebl Thuillier, chercheur en biochimie - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Rapha\u00ebl Thuillier est ing\u00e9nieur de recherche pour le service de biochimie, d\u00e9tach\u00e9 au sein l\u2019unit\u00e9 Inserm U1082 du Pr Thierry Hauet depuis 2008*. Nomm\u00e9 MCU-PH en biochimie \u00e0 la rentr\u00e9e, il int\u00e8gre en parall\u00e8le le laboratoire de biochimie du CHU. Ce scientifique de formation a \u00e9tudi\u00e9 la biologie cellulaire et physiologique en Normandie, avant de mettre le cap sur les Etats-Unis o\u00f9 il a pass\u00e9 sa th\u00e8se. C\u2019est suite \u00e0 la rencontre avec le Pr Hauet, alors post-doctorant \u00e0 l\u2019universit\u00e9 Georgetown \u00e0 Washington, qu\u2019il s\u2019int\u00e9resse \u00e0 la recherche translationnelle, approche qu\u2019il a approfondie pendant trois ann\u00e9es post-doctorales \u00e0 l\u2019institut national de la sant\u00e9 (NIH) aux Etats-Unis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.chu-poitiers.fr\/questions-a-rapahel-thuillier-chercheur-en-biochimie\/\" \/>\n<meta property=\"og:site_name\" content=\"Site du CHU de Poitiers\" \/>\n<meta property=\"article:published_time\" content=\"2016-10-17T14:34:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-04-20T16:05:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.chu-poitiers.fr\/wp-content\/uploads\/2016\/10\/raphael-thuillier.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"553\" \/>\n\t<meta property=\"og:image:height\" content=\"788\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"ChuPoitiers\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ChuPoitiers\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/questions-a-rapahel-thuillier-chercheur-en-biochimie\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/questions-a-rapahel-thuillier-chercheur-en-biochimie\\\/\"},\"author\":{\"name\":\"ChuPoitiers\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#\\\/schema\\\/person\\\/08e92cc802383a84a4efc3b8a6a6658c\"},\"headline\":\"Questions \u00e0 Rapha\u00ebl Thuillier, chercheur en biochimie\",\"datePublished\":\"2016-10-17T14:34:14+00:00\",\"dateModified\":\"2021-04-20T16:05:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/questions-a-rapahel-thuillier-chercheur-en-biochimie\\\/\"},\"wordCount\":475,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/questions-a-rapahel-thuillier-chercheur-en-biochimie\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/wp-content\\\/uploads\\\/2016\\\/10\\\/raphael-thuillier.jpg\",\"articleSection\":[\"Biologie m\u00e9dicale\",\"Recherche\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/questions-a-rapahel-thuillier-chercheur-en-biochimie\\\/\",\"url\":\"https:\\\/\\\/www.chu-poitiers.fr\\\/questions-a-rapahel-thuillier-chercheur-en-biochimie\\\/\",\"name\":\"Questions \u00e0 Rapha\u00ebl Thuillier, chercheur en biochimie - 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