{"id":12758,"date":"2016-09-01T09:30:23","date_gmt":"2016-09-01T07:30:23","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=12758"},"modified":"2021-04-20T18:05:44","modified_gmt":"2021-04-20T16:05:44","slug":"questions-a-laura-hatchondo-chef-de-clinique-en-neurophysiologie","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/questions-a-laura-hatchondo-chef-de-clinique-en-neurophysiologie\/","title":{"rendered":"Questions \u00e0 Laura Hatchondo, chef de clinique en neurophysiologie"},"content":{"rendered":"<p><strong>Docteur Hatchondo, pouvez-vous expliquer votre projet de recherche ?<\/strong><br \/>\nMes travaux de recherche s\u2019articulent autour des sp\u00e9cialit\u00e9s de neurosciences et de neuroimagerie, et sont principalement bas\u00e9s sur la technique de spectroscopie par r\u00e9sonance magn\u00e9tique (SRM) multinoyaux c\u00e9r\u00e9brale, s\u00e9quence d\u2019imagerie par r\u00e9sonance magn\u00e9tique (IRM). Tout a commenc\u00e9 au cours de mon master 1 et se poursuit actuellement pour ma th\u00e8se de sciences. Ces travaux sont encadr\u00e9s par Carole Guillevin, ing\u00e9nieure de recherche au laboratoire DACTIM lab\u00e9lis\u00e9 CNRS, et par le professeur R\u00e9my Guillevin. Nous avons d\u00e9cid\u00e9 d\u2019utiliser la SRM car il s\u2019agit d\u2019une technique innovante et en pleine expansion, qui permet d\u2019\u00e9tudier le m\u00e9tabolisme c\u00e9r\u00e9bral in vivo, de mani\u00e8re non invasive et non irradiante. Le but de cette technique est de fournir des informations d\u2019ordre biochimique sur la composition des tissus explor\u00e9s.\u00a0En effet, les tissus biologiques humains sont compos\u00e9s de m\u00e9tabolites dont la concentration peut varier entre l\u2019\u00e9tat physiologique et pathologique.<\/p>\n<p><strong>Dans quel contexte employez-vous cette technique ?<\/strong><br \/>\nDu master 1 \u00e0 la th\u00e8se de m\u00e9decine, l\u2019objectif de mon travail a \u00e9t\u00e9 de d\u00e9crire et de comparer les modifications m\u00e9taboliques c\u00e9r\u00e9brales en SRM multinoyaux (proton et phosphore), dans certaines r\u00e9gions d\u2019int\u00e9r\u00eat, chez des patients souffrant de troubles obsessionnels du comportement s\u00e9v\u00e8res versus un groupe de sujets sains. Actuellement, pour ma th\u00e8se de sciences, nous compl\u00e9tons ce travail par une \u00e9tude de la stabilit\u00e9 des concentrations de m\u00e9tabolites par trois \u00e9chantillonnages sur 24h chez des sujets sains. Dans l\u2019avenir, nous esp\u00e9rons pouvoir monter des projets de recherche entre neuroimagerie et pathologies du sommeil (ex : narcolepsie, insomnie, syndrome d\u2019apn\u00e9es du sommeil).<\/p>\n<p><strong>Est-ce que la SRM c\u00e9r\u00e9brale peut \u00eatre utilis\u00e9e pour \u00e9tudier d\u2019autres pathologies ?<\/strong><br \/>\nOui, la SRM a d\u00e9j\u00e0 \u00e9t\u00e9 beaucoup utilis\u00e9e en recherche pour d\u2019autres maladies psychiatriques telles que le trouble bipolaire ou la schizophr\u00e9nie, mais aussi dans les maladies neurologiques comme la scl\u00e9rose en plaque. Elle est actuellement utilis\u00e9e en routine dans le cadre des tumeurs c\u00e9r\u00e9brales. En tous les cas, je reste convaincue que c\u2019est par des projets de recherche multidisciplinaires qu\u2019il sera possible de mieux appr\u00e9hender les maladies psychiatriques et neurologiques en m\u00ealant clinique, tests neuropsychologiques, neuroimagerie multimodales et g\u00e9n\u00e9tique. Et ce, dans l\u2019objectif final de pouvoir proposer aux patients une prise en charge plus juste et donc plus efficace.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A 31 ans, le docteur Laura Hatchondo est chef de clinique au sein du service de neurophysiologie clinique \u2013 centre du sommeil au CHU de Poitiers.\u2026","protected":false},"author":1,"featured_media":12759,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[77],"tags":[],"class_list":["post-12758","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurophysiologie"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Questions \u00e0 Laura Hatchondo, chef de clinique en neurophysiologie - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/questions-a-laura-hatchondo-chef-de-clinique-en-neurophysiologie\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Questions \u00e0 Laura Hatchondo, chef de clinique en neurophysiologie - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"A 31 ans, le docteur Laura Hatchondo est chef de clinique au sein du service de neurophysiologie clinique \u2013 centre du sommeil au CHU de Poitiers. 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