{"id":12326,"date":"2016-05-18T15:52:38","date_gmt":"2016-05-18T13:52:38","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=12326"},"modified":"2021-04-20T18:05:38","modified_gmt":"2021-04-20T16:05:38","slug":"questions-a-claire-dahyot-fizelier-anesthesiste-reanimatrice","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/questions-a-claire-dahyot-fizelier-anesthesiste-reanimatrice\/","title":{"rendered":"Questions \u00e0 Claire Dahyot-Fizelier, anesth\u00e9siste-r\u00e9animatrice"},"content":{"rendered":"<p><strong>Vous avez ax\u00e9 vos recherches vers la diffusion des antibiotiques par microdialyse. Comment \u00eates-vous arriv\u00e9e \u00e0 ma\u00eetriser cette technique ?<\/strong><\/p>\n<p>Tout d&#8217;abord, il faut savoir qu&#8217;en France, il y a peu de travaux sur cette technique. En dix-huit ans, huit \u00e9tudes ont \u00e9t\u00e9 men\u00e9e dont cinq \u00e0 Poitiers. On peut dire que nous sommes des pionniers sur le territoire national. J&#8217;ai toujours \u00e9t\u00e9 int\u00e9ress\u00e9e par la recherche, aussi, pendant mon internat, j&#8217;ai rejoint l&#8217;\u00e9quipe Inserm des professeurs William Couet et Olivier Mimoz, U1070. \u00c0 cette \u00e9poque, mes recherches \u00e9taient centr\u00e9es sur la diffusion des antibiotiques par microdialyse dans les tissus musculaires sur les patients de r\u00e9animation. Je me suis ensuite int\u00e9ress\u00e9e \u00e0 la pratique de cette m\u00eame technique pour les tissus c\u00e9r\u00e9braux. Je suis partie \u00e0 Cambridge (Royaume-Uni) en 2007 pour apprendre la microdialyse c\u00e9r\u00e9brale et guider la r\u00e9animation des patients c\u00e9r\u00e9brol\u00e9s\u00e9s. J&#8217;ai r\u00e9alis\u00e9 des \u00e9tudes d&#8217;abord sur les rats, puis j&#8217;ai confirm\u00e9 ces r\u00e9sultats sur les patients de r\u00e9animation.<\/p>\n<p><strong>Et qu&#8217;est -ce que la microdialyse c\u00e9r\u00e9brale ?<\/strong><br \/>\nLa microdialyse permet la mesure de concentrations dans le milieu extracellulaire sans avoir recours \u00e0 une extraction tissulaire. Il faut savoir que la diffusion des antibiotiques dans le cerveau est plus d\u00e9licat car les membranes y sont moins perm\u00e9ables que dans les muscles, par exemple. C&#8217;est un outil de surveillance tr\u00e8s local. Simplement, on va voir si les apports m\u00e9taboliques du patient sont corrects et si les m\u00e9dicaments font effet.<\/p>\n<p><strong>Qu&#8217;en est-il de vos recherches aujourd&#8217;hui ?<\/strong><br \/>\nDeux projets hospitaliers de recherche clinique port\u00e9s par le service d\u2019anesth\u00e9sie-r\u00e9animation ont \u00e9t\u00e9 retenus par la direction g\u00e9n\u00e9rale de l\u2019offre de soins. Le premier est national et concerne l\u2019\u00e9valuation d\u2019un outil pour la r\u00e9duction du risque d\u2019infections pulmonaires chez le traumatis\u00e9 grave avec l\u00e9sion c\u00e9r\u00e9brale. Le second est interr\u00e9gional et porte sur l\u2019administration des antibiotiques pour pr\u00e9venir l\u2019infection pulmonaire chez le patient c\u00e9r\u00e9brol\u00e9s\u00e9. J&#8217;encadre aussi la th\u00e8se de Ludivine Rousseau, interne en anesth\u00e9sie-r\u00e9animation. Elle souhaite apprendre cette technique pour la pratiquer sur des patients de r\u00e9animation cardio-thoracique. Matthieu Boisson, anesth\u00e9siste-r\u00e9animateur, s&#8217;y forme en chirurgie visc\u00e9rale. Les recherches sont permanentes et la microdialyse peut \u00eatre utilis\u00e9e dans les autres sp\u00e9cialit\u00e9s.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>De Caen o\u00f9 elle a d\u00e9but\u00e9 ses \u00e9tudes en m\u00e9decine, Claire Dahyot-Fizelier est arriv\u00e9e \u00e0 Poitiers en 1999 apr\u00e8s avoir \u00e9t\u00e9 nomm\u00e9e interne anesth\u00e9siste-r\u00e9animation\u2026","protected":false},"author":1,"featured_media":12327,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[53],"tags":[],"class_list":["post-12326","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anesthesie"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Questions \u00e0 Claire Dahyot-Fizelier, anesth\u00e9siste-r\u00e9animatrice - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/questions-a-claire-dahyot-fizelier-anesthesiste-reanimatrice\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Questions \u00e0 Claire Dahyot-Fizelier, anesth\u00e9siste-r\u00e9animatrice - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"De Caen o\u00f9 elle a d\u00e9but\u00e9 ses \u00e9tudes en m\u00e9decine, Claire Dahyot-Fizelier est arriv\u00e9e \u00e0 Poitiers en 1999 apr\u00e8s avoir \u00e9t\u00e9 nomm\u00e9e interne anesth\u00e9siste-r\u00e9animation dans le service du professeur Bertrand Debaene. Dot\u00e9e d&#039;un dipl\u00f4me d&#039;\u00e9tudes sp\u00e9cialis\u00e9es en anesth\u00e9sie-r\u00e9animation et d&#039;un dipl\u00f4me d&#039;\u00e9tudes sup\u00e9rieures sp\u00e9cialis\u00e9es en pharmacocin\u00e9tique, Claire Dayhot-Fizelier deviendra ma\u00eetresse de conf\u00e9rence des universit\u00e9\u00a0en 2009, puis professeure en 2016. Elle est aujourd&#039;hui responsable de la r\u00e9animation neurochirurgicale et chirurgicale du CHU. \u00c0 la fin de son internat, la praticienne a travaill\u00e9 sur la distribution des antibiotiques dans les tissus musculaires par microdialyse chez les patients en r\u00e9animation. 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