{"id":12296,"date":"2016-05-12T10:20:42","date_gmt":"2016-05-12T08:20:42","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=12296"},"modified":"2021-04-20T18:05:38","modified_gmt":"2021-04-20T16:05:38","slug":"questions-a-francois-charles-javaugue-bacteriologiste","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/questions-a-francois-charles-javaugue-bacteriologiste\/","title":{"rendered":"Questions \u00e0 Fran\u00e7ois-Charles Javaugue, bact\u00e9riologiste"},"content":{"rendered":"

De nombreux travaux de recherche sont men\u00e9s sur le sujet, mais vous avez choisi de diss\u00e9quer le Sida sous toutes ses formes : \u00e9pid\u00e9miologique, mais aussi historique, g\u00e9ographique, sociale… Qu\u2019apporte ce nouvel \u00e9clairage sur le virus ?
\n<\/strong>La qu\u00eate des origines n\u2019\u00e9pargne pas les virologues\u2026 Les donn\u00e9es virologiques (“phylog\u00e9n\u00e9tiques”) nous ont permis de retracer l\u2019origine et la diffusion des diff\u00e9rents sous-types VIH-1 \u00e0 travers le monde, le VIH \u00e9tant class\u00e9 en plusieurs sous-types qui ont tous leur propre histoire. La pand\u00e9mie est le r\u00e9sultat d\u2019un unique \u00e9v\u00e9nement de transmission zoonotique d\u2019un virus ancestral du singe \u00e0 l\u2019Homme, en l\u2019occurrence du chimpanz\u00e9 \u00e0 l\u2019Homme, par la chasse et la consommation de viande de brousse, aux alentours de 1908, dans une r\u00e9gion recul\u00e9e du sud-est du Cameroun. Cette \u00e9tape a \u00e9crit l\u2019acte fondateur de la pand\u00e9mie. La diversification chez l\u2019Homme de ce virus simien a donn\u00e9 naissance aux diff\u00e9rents sous-types VIH-1.<\/p>\n

Les premi\u00e8res traces du virus sont ensuite document\u00e9es en 1959 \u00e0 Kinshasa, en Ha\u00efti, d\u00e8s 1966, avant d\u2019\u00e9merger aux \u00c9tats-Unis en 1971, soit douze ans avant la d\u00e9couverte du virus \u00e0 l\u2019Institut Pasteur de Paris. Cette diffusion pand\u00e9mique est le r\u00e9sultat d\u2019une conjonction in\u00e9dite au XXe<\/sup> si\u00e8cle de facteurs d\u00e9mographiques, socio-\u00e9conomiques (d\u00e9veloppement des transports, exode rural, conflits et migrations de populations), culturels (changement des pratiques sexuelles) et m\u00e9dicaux (campagnes massives d\u2019injection de pentamidine et de p\u00e9nicilline dans les ann\u00e9es 1950 en Afrique). Pour la premi\u00e8re fois, cet ouvrage retrace la diffusion des virus du Sida dans le temps et l\u2019espace, pour comprendre l\u2019\u00e9pid\u00e9mie d\u2019hier et d\u2019aujourd\u2019hui et ainsi mieux appr\u00e9hender celle de demain, pour une riposte plus efficace.<\/p>\n

Trentre\u00a0ans apr\u00e8s la d\u00e9couverte du virus, aucun vaccin pr\u00e9ventif n\u2019a encore \u00e9t\u00e9 d\u00e9couvert. Quelles peuvent \u00eatre les formes de cette “riposte” ?
\n<\/strong>La route est encore longue pour tordre le cou aux id\u00e9es re\u00e7ues sur le SIDA\u2026 Il faut poursuivre le travail d\u2019information et de pr\u00e9vention. On recense 35 millions de personnes infect\u00e9es dans le monde, 130 000 en France, dont 20% qui ignorent leur s\u00e9ropositivit\u00e9. Malgr\u00e9 les progr\u00e8s enregistr\u00e9s dans de nombreux pays, seulement 37% des personnes vivant avec le VIH re\u00e7oivent un traitement antir\u00e9troviral. Doubl\u00e9 du b\u00e9n\u00e9fice individuel direct, ce traitement r\u00e9duit consid\u00e9rablement le risque de transmission virale. Des perspectives encourageantes (“test and treat”) ont fait germer l\u2019id\u00e9e de “z\u00e9ro nouvelle infection \u00e0 l\u2019horizon 2020”, \u00e0 condition de d\u00e9pister et de traiter l\u2019ensemble de la population s\u00e9ropositive. Vaccin efficace, pr\u00e9vention, d\u00e9pistage et traitement pr\u00e9coce (voire pr\u00e9ventif) sont les actions de lutte essentielles contre ce fl\u00e9au.<\/p>\n

Quelle est aujourd\u2019hui votre activit\u00e9 m\u00e9dicale en bact\u00e9riologie au CHU ?<\/strong>
\nNous assurons le diagnostic microbiologique et le suivi des infections bact\u00e9riennes, les missions d\u2019enseignement et de recherche. Le laboratoire est dot\u00e9 de techniques performantes pour r\u00e9aliser culture, identification et antibiogramme et r\u00e9pondre au mieux aux attentes de nos coll\u00e8gues cliniciens. C\u2019est un partenaire dynamique et privil\u00e9gi\u00e9 des services de soins. L\u2019unit\u00e9 d\u2019hygi\u00e8ne hospitali\u00e8re assure les missions de surveillance et de pr\u00e9vention des infections nosocomiales. Des techniques nouvelles sont amen\u00e9es \u00e0 se d\u00e9velopper. La veille scientifique et technologique exerc\u00e9e par l\u2019ensemble de l\u2019\u00e9quipe, sous l\u2019impulsion du Pr Burucoa, est particuli\u00e8rement motivante pour rendre encore plus performant le diagnostic des maladies infectieuses.<\/p>\n","protected":false},"excerpt":{"rendered":"

Charentais d\u2019origine, le Dr Fran\u00e7ois-Charles Javaugue d\u00e9bute ses \u00e9tudes \u00e0 la facult\u00e9 de Poitiers en 1998 avant de prendre la direction de Bordeaux\u2026","protected":false},"author":1,"featured_media":12297,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-12296","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nQuestions \u00e0 Fran\u00e7ois-Charles Javaugue, bact\u00e9riologiste - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/en\/questions-a-francois-charles-javaugue-bacteriologiste\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Questions \u00e0 Fran\u00e7ois-Charles Javaugue, bact\u00e9riologiste - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Charentais d\u2019origine, le Dr Fran\u00e7ois-Charles Javaugue d\u00e9bute ses \u00e9tudes \u00e0 la facult\u00e9 de Poitiers en 1998 avant de prendre la direction de Bordeaux pour son internat en biologie m\u00e9dicale. 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