{"id":120957,"date":"2022-06-10T16:17:30","date_gmt":"2022-06-10T14:17:30","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=120957"},"modified":"2022-06-10T16:17:32","modified_gmt":"2022-06-10T14:17:32","slug":"sport-et-collection-500-ferrari-contre-le-cancer-merci","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/sport-et-collection-500-ferrari-contre-le-cancer-merci\/","title":{"rendered":"Sport et collection \u00ab\u00a0500 Ferrari contre le cancer\u00a0\u00bb, merci\u00a0!"},"content":{"rendered":"\n<p>Les belles voitures attirent toujours autant de monde. Pour preuve, les visiteurs venus en nombre pour admirer le millier de v\u00e9hicules de prestige expos\u00e9s aux abords du circuit Val-de-Vienne. Il y en avait pour tous les go\u00fbts, des plus anciennes datant de 1950 aux plus modernes. Entre stands, parades et animations, les spectateurs ont aussi eu la chance d\u2019assister \u00e0 des spectacles a\u00e9riens de l\u2019arm\u00e9e de l\u2019air, partenaire fid\u00e8le. \u00ab 500 Ferrari contre le cancer \u00bb est pour le CHU de Poitiers un \u00e9v\u00e8nement essentiel, les dons obtenus permettant de financer des projets de recherche. Cette ann\u00e9e, ce sont les projets du <strong>Pr Lucie Karayan-Tapon, <\/strong>chef du service de canc\u00e9rologie biologique, du <strong>Dr Emilie Cayssals et Dr Thomas Systchenko<\/strong>, du service h\u00e9matologie et th\u00e9rapie cellulaire, qui b\u00e9n\u00e9ficieront des dons r\u00e9colt\u00e9s. La manifestation est \u00e9galement l\u2019occasion pour les chercheurs et les professionnels du CHU de Poitiers de communiquer sur les avanc\u00e9es th\u00e9rapeutiques. Ils adressent tous les remerciements aux organisateurs, aux propri\u00e9taires de v\u00e9hicules, aux partenaires, aux b\u00e9n\u00e9voles et au public qui, chaque ann\u00e9e, se mobilisent pour faire avancer la recherche.<\/p>\n<p><strong>PROgression et DIs\u00e9mination CEr\u00e9bralesdes cellules Tumorales (ProDiCeT)<\/strong><strong><br \/>Statut et r\u00f4le du syst\u00e8mes prot\u00e9ine S \/ r\u00e9cepteurs tyrosine kinase TAM dans la progression des tumeurs primitives du colon et la formation de m\u00e9tastases c\u00e9r\u00e9brales<\/strong><\/p>\n<p>Le projet de recherche est centr\u00e9 sur deux pathologies relatives \u00e0 l\u2019envahissement c\u00e9r\u00e9bral des tumeurs : les gliomes, tumeurs primitives du syst\u00e8me nerveux central localement invasives, et les m\u00e9tastases c\u00e9r\u00e9brales, tumeurs c\u00e9r\u00e9brales secondaires des cancers colorectaux et des cancers mammaires. L\u2019objectif est d\u2019\u00e9tudier les processus cellulaires et m\u00e9canismes mol\u00e9culaires impliqu\u00e9s dans la diss\u00e9mination c\u00e9r\u00e9brale et de contribuer \u00e0 l\u2019\u00e9laboration d\u2019approches th\u00e9rapeutiques centr\u00e9es sur l\u2019inhibition cibl\u00e9e d\u2019\u00e9v\u00e9nements relatifs \u00e0 la croissance et\/ou la diss\u00e9mination tumorales dans le cerveau. La caract\u00e9risation fonctionnelle et l\u2019exploration des r\u00f4les potentiels du syst\u00e8me ProS\/r\u00e9cepteurs dans la diss\u00e9mination des cellules tumorales de cancer colorectal au cerveau est l\u2019objet principal de l\u2019\u00e9tude qui va b\u00e9n\u00e9ficier du soutien de Sport et Collection.<\/p>\n<p>Le ciblage des r\u00e9cepteurs tyrosine kinase TAM pourrait constituer une nouvelle voie th\u00e9rapeutique dans le cancer colorectal m\u00e9tastatique. Ces travaux permettront d\u2019une mani\u00e8re g\u00e9n\u00e9rale de mieux comprendre les m\u00e9canismes physiopathologiques li\u00e9s \u00e0 la diss\u00e9mination des cellules tumorales au cerveau et seront transposables \u00e0 d\u2019autres tumeurs.<\/p>\n<p><strong>LMC et seconds cancers primitifs (SCP)\u00a0: incidence et prise en charge. Etude ancillaire \u00e0 l\u2019essai fran\u00e7ais SPIRIT, observationnelle, analytique, longitudinale, de type cohorte historique multicentrique<\/strong><\/p>\n<p>Dans le monde 1 cancer sur 10 est un second cancer primitif. Le second cancer primitif est un nouveau cancer, qui n\u2019est pas un d\u00e9veloppement du premier mais qui est totalement diff\u00e9rent. La d\u00e9claration de ce second cancer primitif peut poser des probl\u00e9matiques par rapport au traitement choisi. Les oncologues doivent alors adapter le choix du second traitement sans entraver l\u2019efficacit\u00e9 du premier.<\/p>\n<p>Le projet de recherche propose de se focaliser sur la leuc\u00e9mie my\u00e9lo\u00efde chronique et son traitement par imatinib. L\u2019imatinib inhibe la tyrosine kinase oncog\u00e9nique BCR-ABL mais \u00e9galement la prot\u00e9ine ABL. Il peut ainsi bloquer la fonction \u00ab suppresseur de tumeur \u00bb de l\u2019ABL et avoir un r\u00f4le promoteur dans la progression tumorale. A ce jour les r\u00e9sultats publi\u00e9s sont discordants \u00e0 ce sujet. L\u2019\u00e9tude recueillera r\u00e9trospectivement les strat\u00e9gies th\u00e9rapeutiques des diff\u00e9rents centres, les d\u00e9crira, puis les synth\u00e9tisera pour proposer des recommandations d\u2019experts.<\/p>\n<p><strong>Analyse par cytom\u00e9trie spectrale et application du concept de l\u2019innateness pour d\u00e9finir une signature immunitaire pr\u00e9dictive du succ\u00e8s d\u2019arr\u00eat de traitement dans la leuc\u00e9mie my\u00e9lo\u00efde chronique. <\/strong><\/p>\n<p><strong>Dr Emilie CAYSSIALS, <\/strong>service h\u00e9matologie et th\u00e9rapie cellulaire<\/p>\n<p>Le pronostic de la leuc\u00e9mie my\u00e9lo\u00efde chronique a \u00e9t\u00e9 r\u00e9volutionn\u00e9 par le d\u00e9veloppement d\u2019inhibiteurs de tyrosine kinase mais dont l\u2019utilisation th\u00e9rapeutique doit g\u00e9n\u00e9ralement \u00eatre poursuivie au long cours du fait de la persistance d\u2019une maladie r\u00e9siduelle. En 2007 un groupe fran\u00e7ais a propos\u00e9 \u00e0 des patients d\u2019arr\u00eater ce traitement par inhibiteur pour \u00e9tudier l\u2019\u00e9volution de la maladie suite \u00e0 cet arr\u00eat. 50 % des patients ont alors eu une progression de la maladie et ont d\u00fb reprendre leur traitement et les autres 50 % ont eu une r\u00e9ponse. L\u2019hypoth\u00e8se est que le syst\u00e8me immunitaire de ces patients prend le relais du traitement. Le projet de recherche propose une approche globale des diff\u00e9rents \u00e9l\u00e9ments cellulaires immunitaires d\u2019int\u00e9r\u00eat, permise par l\u2019acquisition r\u00e9cente d\u2019un analyseur multiparam\u00e9trique \u00e0 l\u2019\u00e9chelle cellulaire reposant sur une nouvelle technologie, la cytom\u00e9trie en flux spectral. Guid\u00e9e par le concept de gradient d\u2019innateness, l\u2019\u00e9quipe de recherche est en mesure de d\u00e9finir un score global d\u2019immunit\u00e9 inn\u00e9e. En comparant les \u00e9chantillons des patients ayant r\u00e9ussi l\u2019arr\u00eat du traitement par inhibiteur de tyrosine kinase \u00e0 ceux des patients ayant \u00e9chou\u00e9 l\u2019\u00e9quipe pense pouvoir d\u00e9finir un score pronostique immunitaire permettant de pr\u00e9dire la r\u00e9mission apr\u00e8s arr\u00eat du traitement.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Apr\u00e8s deux ann\u00e9es difficiles en raison de la crise sanitaire, la manifestation organis\u00e9e par l\u2019association Sport et collection, \u00ab\u00a0500 Ferraris\u2026","protected":false},"author":1,"featured_media":121159,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[96],"tags":[],"class_list":["post-120957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sport et collection \u00ab\u00a0500 Ferrari contre le cancer\u00a0\u00bb, merci\u00a0! - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/sport-et-collection-500-ferrari-contre-le-cancer-merci\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sport et collection \u00ab\u00a0500 Ferrari contre le cancer\u00a0\u00bb, merci\u00a0! - Site du CHU de Poitiers\" \/>\n<meta property=\"og:description\" content=\"Apr\u00e8s deux ann\u00e9es difficiles en raison de la crise sanitaire, la manifestation organis\u00e9e par l\u2019association Sport et collection, \u00ab\u00a0500 Ferraris contre le cancer\u00a0\u00bb, a rencontr\u00e9 un v\u00e9ritable succ\u00e8s pour sa 28e \u00e9dition qui s\u2019est tenue, du 3 au 5 juin, sur le circuit Val-de-Vienne au Vigeant (86). 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