{"id":11119,"date":"2016-02-17T10:57:39","date_gmt":"2016-02-17T09:57:39","guid":{"rendered":"https:\/\/www.chu-poitiers.fr\/?p=11119"},"modified":"2016-02-17T10:58:24","modified_gmt":"2016-02-17T09:58:24","slug":"recherche-quand-le-medicament-devient-intelligent","status":"publish","type":"post","link":"https:\/\/www.chu-poitiers.fr\/en\/recherche-quand-le-medicament-devient-intelligent\/","title":{"rendered":"Recherche : quand le m\u00e9dicament devient intelligent"},"content":{"rendered":"

Fabriquer une mol\u00e9cule m\u00e9dicamenteuse qui cible de fa\u00e7on pr\u00e9cise la tumeur. Voil\u00e0 une perspective stimulante qui mobilise depuis longtemps de nombreux chercheurs du monde entier avec l\u2019objectif d\u2019am\u00e9liorer l\u2019efficacit\u00e9 du m\u00e9dicament, et en limiter les effets secondaires d\u00e9sagr\u00e9ables ou invalidants \u2013 comme la perte de poids, de cheveux ou d\u2019app\u00e9tit. Aujourd\u2019hui, le but semble plus proche que jamais, gr\u00e2ce aux recherches du Dr Jonathan Clarhaut, chercheur au CHU de Poitiers. “Dans les traitements anticanc\u00e9reux, bien trop d\u2019effets secondaires perturbent la vie du patient”, explique le scientifique, dont le parcours s\u2019est concr\u00e9tis\u00e9 en 2008 au sein de l\u2019universit\u00e9 de Poitiers par une th\u00e8se de doctorat sur les aspects mol\u00e9culaires et cellulaires de la biologie, portant pr\u00e9cis\u00e9ment sur l\u2019\u00e9tude de la r\u00e9gulation de l\u2019expression de la s\u00e9maphorine 3F antitumorale.<\/p>\n

\"La
La recherche s\u2019est effectu\u00e9e en collaboration entre le CHU et le groupe “Syst\u00e8mes mol\u00e9culaires programm\u00e9s” dirig\u00e9 par le professeur S\u00e9bastien Papot au sein de l\u2019Institut de chimie des milieux et des mat\u00e9riaux de Poitiers (CNRS-UMR7285).<\/figcaption><\/figure>\n

D\u00e8s cet instant, gr\u00e2ce \u00e0 un contrat de chercheur au sein du CHU, le jeune scientifique se consacrait \u00e0 la mise au point de g\u00e2chettes qui permettent aux m\u00e9dicaments de circuler librement dans le plasma sans traverser la membrane des cellules saines, avant d\u2019\u00eatre lib\u00e9r\u00e9s au sein de la tumeur. Greff\u00e9e sur le m\u00e9dicament, cette g\u00e2chette bloque son entr\u00e9e dans les cellules lambda et s\u2019active au moment o\u00f9 elle doit agir : au coeur de la maladie.<\/p>\n

En pratique, c\u2019est en d\u00e9veloppant un syst\u00e8me de mol\u00e9cules vectoris\u00e9es que le r\u00e9sultat recherch\u00e9 a \u00e9t\u00e9 atteint. Dot\u00e9e d\u2019un noyau auto-catalytique qui bloque sa lib\u00e9ration pr\u00e9matur\u00e9e, la mol\u00e9cule circule dans le corps humain jusqu\u2019\u00e0 atteindre son objectif o\u00f9 le programme mol\u00e9culaire qui lui est int\u00e9gr\u00e9 lib\u00e8re tout son potentiel th\u00e9rapeutique. Cette ouverture planifi\u00e9e et contr\u00f4l\u00e9e de la mol\u00e9cule par lib\u00e9ration enzymatique constitue un saut qualitatif ind\u00e9niable dans l\u2019administration d\u2019un m\u00e9dicament et ouvre les possibilit\u00e9s d\u2019un traitement s\u00e9lectif.<\/p>\n

“Polychimioth\u00e9rapie cibl\u00e9e”<\/strong>
\nAu stade actuel de recherche, “des discussions avanc\u00e9es sont en cours avec un groupe industriel afin de vendre les licences d\u2019exploitation de nos m\u00e9dicaments intelligents et des essais cliniques pourraient \u00eatre planifi\u00e9es pour 2017”, note le Dr Clarhaut. Actuellement, les r\u00e9sultats obtenus permettent d\u2019envisager un essai clinique pour lequel l\u2019appui d\u2019un groupe industriel sera n\u00e9cessaire avant de donner des traductions concr\u00e8tes \u00e0 ce principe chez l\u2019homme. Toutes ces op\u00e9rations ont un co\u00fbt tr\u00e8s important qui rend n\u00e9cessaire l\u2019entr\u00e9e en jeu d\u2019un grand laboratoire. “Outre ces travaux, nous poursuivons nos investigations \u00e0 la recherche de mol\u00e9cules anticanc\u00e9reuses toujours plus performantes et cibl\u00e9es, ajoute-t-il. Notre prochain challenge est de d\u00e9velopper une polychimioth\u00e9rapie cibl\u00e9e qui va consister \u00e0 utiliser en parall\u00e8le plusieurs classes de nos m\u00e9dicaments intelligents, qui auront des m\u00e9canismes d\u2019action compl\u00e9mentaires, afin d\u2019attaquer la tumeur par diff\u00e9rents angles et d\u2019am\u00e9liorer les chances de l\u2019\u00e9liminer totalement.”<\/p>\n

De plus, le dispositif pourrait \u00eatre utilis\u00e9 dans d\u2019autres maladies que le cancer. “Dans l\u2019absolu, il est transf\u00e9rable \u00e0 d\u2019autres agents traitants”, observe le Dr Clarhaut. \u00c0 noter que ces recherches ont b\u00e9n\u00e9fici\u00e9 de l\u2019appui des associations Ligue contre le cancer et France-ADOT 86 ainsi que de l\u2019initiative Sport et collection qui r\u00e9unit chaque ann\u00e9e des amateurs de belles voitures sur le circuit du Vigeant.<\/p>\n","protected":false},"excerpt":{"rendered":"

Fabriquer des m\u00e9dicaments qui ciblent de mani\u00e8re pr\u00e9cise leur objectif devient une perspective r\u00e9aliste gr\u00e2ce aux recherches d\u2019un jeune chercheur\u2026","protected":false},"author":1,"featured_media":11120,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[41],"tags":[],"class_list":["post-11119","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche"],"acf":[],"yoast_head":"\nRecherche : quand le m\u00e9dicament devient intelligent - Site du CHU de Poitiers<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.chu-poitiers.fr\/recherche-quand-le-medicament-devient-intelligent\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recherche : quand le m\u00e9dicament devient intelligent - 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